Abstract
Infection with viruses and bacteria generally results in robust induction of the innate immune response followed by the generation of an antigen-specific adaptive immune response comprised of CD4 and CD8 T cells and B cells. Thus, there are multiple cellular players in the induction of the response and although our knowledge has increased dramatically in recent years, there is much to learn regarding the complex interplay of the various cell types necessary in mounting a productive, and potentially protective, immune response. Long-term protection following infection or vaccination is mediated by memory T and B cells, as well as by circulating neutralizing antibody. The molecular and cellular requirements for generation and maintenance of immunological memory are largely unknown, although recent studies have begun to yield some intriguing clues in this area.
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Lefrançois, L., Marzo, A., Masopust, D., Schluns, K., Vezys, V. (2002). Migration of Primary and Memory Cd8 T Cells. In: Gupta, S., Butcher, E., Paul, W. (eds) Lymphocyte Activation and Immune Regulation IX. Advances in Experimental Medicine and Biology, vol 512. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0757-4_19
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DOI: https://doi.org/10.1007/978-1-4615-0757-4_19
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