Abstract
The pre-ocular tear film consists of an inner mucus layer that coats the epithelial surface, a middle aqueous layer containing soluble mucins and other proteins and an outermost lipid layer.1 Deficits in tear film mucins have been associated with several dry eye disorders,2–6suggesting that ocular mucin secretogogues may have therapeutic benefit for treatment of dry eye. Current evidence suggests that ocular surface epithelia express a diverse array of mucins, including MUC1, MUC2, MUC4, MUC5AC and MUC7.7–9 However, the physiological functions of individual tear film mucins remain largely unexplored.
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Jumblatt, J.E., Cunningham, L., Jumblatt, M.M. (2002). Effects of 15(S)-HETE on Human Conjunctival Mucin Secretion. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_46
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_46
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