Abstract
In humans and experimental animals, carcinogenesis is a complex process in which normal cell growth is modified. Carcinogenesis is divided into three main stages: initiation, promotion and progression. Chemopreventive interaction in carcinogenesis offers two major strategies. The first strategy will inhibit or at least slow down carcinogenesis by blocking its progress. This might occurr at all stages of carcinogenesis. This strategy includes the scavenging of bioreactive intermediates (BRIs), induction or inhibition of enzymes of the metabolism of xenobiotics which create or detoxify the BRIs, of enzymes of DNA-repair or of other enzymes. A second strategy aims at reversing the process of tumour formation either by redifferentiation of transformed cells or the elimination of precarcinogenic clones. Both strategies cover one or several steps of carcinogenesis and approach the subject matter in more general terms without consideration of individual susceptibility to particular cancers (Kelloff et al., 1999).
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Thier, R. (2001). Chemoprotection and Interindividual Differences in Response to Biological Reactive Intermediates. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_87
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DOI: https://doi.org/10.1007/978-1-4615-0667-6_87
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