Abstract
Oxidative stress has been recognized to be an important mechanism of toxic action of many compounds, such as quinones or peroxides. Increased production of reactive oxygen species (ROS) can cause significant changes in cellular redox state and may lead to: 1) adverse alterations in gene expression (Toyokuni et al. 1995), or 2) oxidative damage to cellular molecules, i.e. proteins, DNA, and phospholipids (de Zwart et al. 1999).
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Bláha, L., Machala, M., Vondráček, J., Breineková, K. (2001). Multiple Oxidative Stress Parameters are Modulated in Vitro by Oxygenated Polycyclic Aromatic Hydrocarbons Identified in River Sediments. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_32
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DOI: https://doi.org/10.1007/978-1-4615-0667-6_32
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