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Oxidative Stress and the Structure/Activity Relationships of Ergopeptide Alkaloids

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Biological Reactive Intermediates VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 500))

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Abstract

Oxidative stress is responsible for generating oxygen or non-oxygen free radicals, which are generally short:lived and highly reactive. It is well known1 that such radicals proliferate in degenerative diseases, when their production overwhelms the body’s defensive mechanisms. It has been suggested that free radicals may adversely influence the pathogenesis of Parkinson’s disease (PD).

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References

  1. I. N. Acworth, D. P. B. Bailey, The handbook of oxidative metabolism, ESA, Inc. (1996)

    Google Scholar 

  2. T. Yoshikawa, Y. Minamiyama, Y. Naito, and M. Kondo, Antioxidant properties of bromocriptine, a dopamine agonist, J. Neurochem. 62:1034 (1994).

    Article  PubMed  CAS  Google Scholar 

  3. M. Gomez-Vargas, S. Nishibayashi-Asanuma, M. Asanuma, Y. Kondo, E. Iwata, and N. Ogawa, Pergolide scavenges both hydroxyl and nitric oxide free radicals in vitro and inhibits lipid peroxidation in different regions of the rat brain, Brain Res. 790:202 (1998).

    Article  PubMed  CAS  Google Scholar 

  4. M. Tanaka, A. Sotomatsu, T. Yoshida, and S. Hirai, Inhibitory effects of bromocriptine on phospholipid peroxidation induced by DOPA and iron, Neuroscience letters 183:116 (1995).

    Article  PubMed  CAS  Google Scholar 

  5. M.A. Peyronneau, M. Delaforge, R. Rivière, J.P. Renaud, and D. Mansuy, High affinity of ergopeptides for cytochromes P450 3A: importance of their peptide moiety for P450 recognition and hydroxylation of bromocriptine, Eur. J. Biochem. 223:947 (1994).

    Article  CAS  Google Scholar 

  6. J. Pré, Revue générale: la lipoperoxidation, Path. Biol. 39:716 (1991).

    Google Scholar 

  7. K. Yagi, Simple assay for the level of total lipid peroxides in serum or plasma, Methods in molecular biology, Free radical and antioxidant protocols, 108:101 (1998).

    Article  CAS  Google Scholar 

  8. G. Maurer, E. Scheirer, S. Delaborde, R. Nufer, and A.P. Shukla, Fate and disposition of bromocriptine in animals and man 2: Absorption, elimination and metabolism, Eur. J. Drug. Metab. Pharmacokinet. 8:51 (1983).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Département de Recherche Médicale, Direction des Sciences du Vivant, Service de Pharmacologie et d’;Immunologie, CEA-Saclay, Bât. 136, F-91191, Gif sur Yvette, France

    Fabrice Bensaude & Marcel Delaforge

  2. URA 2096 CNRS « Protéines membranaires transductrices d’énergie », France

    Geneviève Bouillé & Marcel Delaforge

Authors
  1. Fabrice Bensaude
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  2. Geneviève Bouillé
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  3. Marcel Delaforge
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Editor information

Editors and Affiliations

  1. Université René Descartes, Paris, France

    Patrick M. Dansette

  2. Rutgers University and The Environmental & Occupational Health Sciences Institute, Piscataway, New Jersey, USA

    Robert Snyder

  3. CNRS, Paris, France

    Marcel Delaforge

  4. University of Surrey, Guildford, Surrey, England

    G. Gordon Gibson

  5. Institute of Toxicology and Environmental Health, The Technical University of Munich, Munich, Germany

    Helmut Greim

  6. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  7. University of Texas, Austin, Texas, USA

    Terrence J. Monks

  8. University of Arizona, Tucson, Arizona, USA

    I. Glenn Sipes

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© 2001 Springer Science+Business Media New York

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Bensaude, F., Bouillé, G., Delaforge, M. (2001). Oxidative Stress and the Structure/Activity Relationships of Ergopeptide Alkaloids. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_31

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  • DOI: https://doi.org/10.1007/978-1-4615-0667-6_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5185-6

  • Online ISBN: 978-1-4615-0667-6

  • eBook Packages: Springer Book Archive

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