Abstract
Specific human milk oligosaccharides inhibit specific microbial pathogens.1 As soluble homologs or analogs of host receptors for pathogens, milk oligosaccharides, especially fucosylated neutral oligosaccharides, may act as decoys to protect infants against disease.2-4 To study a relationship between specific human milk oligosaccharides and disease in breast-fed infants, it is necessary to know the levels of specific oligosaccharides present in milks of individuals during lactation. Variation in total oligosaccharides, specific α1,2-linked oligosaccharides, and activities of fucosidases and fucosyltransferases has been reported.5, 6This study measures variation in individual fucosylated oligosaccharides in milks of individual mothers over the course of lactation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Newburg, D.S. (1996) Oligosaccharides and glycoconjugates in human milk: Their role in host defense.J. Mammary Gland Biol. Neoplasia 1, 271–283.
Cervantes, L.E., Newburg, D.S. and Ruiz-Palacios, O.M. (1995) α1–2 Fucosylated chains (H-2 and Lewisb) are the main human milk receptor analogs forCampylobacter. Pediatr. Res.37, 171A.
Ruiz-Palacios, G.M., Cervantes, L.E., Newburg, D.S., Lopez-Vidal, Y. and Calva, J.J. (1992).In vitro models for studying Campylobacter jejuni infections. In Nachamkin, I., M.J. Blaser and L.S. Tomkins (eds.),Campylobacter jejuni. Current Status and Future Trends.American Society for Microbiology, Washington, D.C. pp. 176–183.7
Crane, J.K., Azar, S.S., Stam, A. and Newburg, D.S. (1994) Oligosaccharides from human milk block binding and activity of the Escherichia coli heat-stable enterotoxin (STa) in T84 intestinal cells.J. Nutr. 124,2358–2364.
Viverge, D., Grimmonprez, L., Cassanas, G., Bardet, L. and Solere, M. (1990) Discriminant carbohydrate components of human milk according to donor secretor types.J. Pediatr. Gastroenterol. Nutr. 11,365–370.
Wiederschain, G.Y. and Newburg, D.S. (1995) Human milk fucosyltransferase and α-L-fucosidase activities change during the course of lactation.J. Nutr. Biochem.6,582–587.
Coppa, G.V., Gabrielli, O., Pierani, P., Catassi, C., Carlucci, A. and Giorgi, P.L. (1993) Changes in carbohydrate composition in human milk over 4 months of lactation.Pediatrics 91,637–641.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Newburg, D.S. et al. (2002). Milk Oligosaccharides Vary within Individuals and During Lactation. In: Davis, M.K., Isaacs, C.E., Hanson, L.Å., Wright, A.L. (eds) Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation. Advances in Experimental Medicine and Biology, vol 503. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0559-4_54
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0559-4_54
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5132-0
Online ISBN: 978-1-4615-0559-4
eBook Packages: Springer Book Archive