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Modulation of Cyclooxygenase-2 Expression by Apc In Ht-29 Human Colorectal Carcinoma Cells

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 507))

Abstract

Cyclooxygenase (COX) is the key enzyme in arachidonate metabolism and catalyzes the conversion of arachidonic acid to prostaglandin H2, the precursor for prostaglandins and thromboxanes’. Two isoforms of the COX enzyme exist. COX-1 is constitutively expressed in tissues while COX-2 is induced in inflammatory reactions’ dysregulated after loss of APC function.

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Authors and Affiliations

  1. Eicosanoid Biochemistry Section Laboratory of Molecular Carcinogenesis Research Triangle Park, National Institute of Environmental Health Sciences, NC, 27709

    Linda C. Hsi, Julie Angerman-Stewart & Thomas E. Eling

Authors
  1. Linda C. Hsi
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  2. Julie Angerman-Stewart
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  3. Thomas E. Eling
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Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California-San Diego, La Jolla, California, USA

    Edward Dennis

  5. Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Charles Serhan

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© 2002 Springer Science+Business Media New York

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Hsi, L.C., Angerman-Stewart, J., Eling, T.E. (2002). Modulation of Cyclooxygenase-2 Expression by Apc In Ht-29 Human Colorectal Carcinoma Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_21

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  • DOI: https://doi.org/10.1007/978-1-4615-0193-0_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4960-0

  • Online ISBN: 978-1-4615-0193-0

  • eBook Packages: Springer Book Archive

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