Abstract
This case discusses the pharmacokinetic interaction between metoprolol and diphenhydramine. Metoprolol is a cytochrome P450 2D6 substrate. Diphenhydramine is a 2D6 inhibitor. Coadministration results in metoprolol toxicity.
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Wittwer, E.D., Sprung, J. (2015). Better Sleep but Slower Heart. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_128
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DOI: https://doi.org/10.1007/978-1-4614-7495-1_128
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