Definition
Biological phenomenon. Spike-timing-dependent plasticity (STDP) in its narrow sense refers to the change in the synaptic strength as a result of repeatedly triggering pairs of action potentials (“spikes”) with a fixed time difference between the pre- and postsynaptic action potentials (Markram et al. 1997; Bi and Poo 1998; Sjostrom et al. 2001). STDP is typically observed for synapses between hippocampal or cortical pyramidal neurons in slices of juvenile rodents, and the spike pairings are repeated 50–100 times with various frequencies, e.g. 1 or 10 Hz. This protocol induces a change in the amplitude of a single excitatory postsynaptic potential (EPSP) which is plotted against the spike time difference Δt = t post–t pre between the postsynaptic spike and the presynaptic spike (Fig. 1). The change takes in many cases a few minutes to be expressed and lasts at least for the...
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Senn, W., Pfister, JP. (2014). Spike-Timing-Dependent Plasticity, Learning Rules. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_683-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_683-1
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