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Encyclopedia of Signaling Molecules pp 1–11Cite as

Synapsin II

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Synonyms

SYN2; SYNII; Synapsin 2; Synapsin II

Historical Background

Synapsin II (SYN2) was identified in the late 1970s following studies that began searching for neuronal substrates for endogenous cyclic adenosine 3′:5′ monophosphate (cAMP)-dependent phosphorylation. cAMP had been suggested to mediate neurotransmitter regulation through synaptic membrane proteins and led to the discovery of several proteins including the family of synapsin proteins. Highly specific to nerve terminals, synapsins were among one of the first identified synaptic vesicle-associated protein families (De Camilli et al. 1990).

The first member identified in the synapsin family was synapsin I, initially named protein I, and described by Paul Greengard in 1972 as a primary synaptic membrane phosphorylation target by cAMP-dependent kinases (Johnson et al. 1972). Following the discovery of synapsin I, a second member of the synapsin family – protein III – later renamed synapsin II (SYN2) was identified in the...

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References

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Acknowledgments

The work described in this review was supported by the Canadian Institute of Health Research (CIHR).

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Authors and Affiliations

  1. McMaster Integrative Neuroscience Discovery and Study, McMaster University, Hamilton, ON, Canada

    Ashley Bernardo, Shreya Prashar & Luke Molinaro

  2. Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, ON, Canada

    Ram Mishra

Authors
  1. Ashley Bernardo
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  2. Shreya Prashar
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  3. Luke Molinaro
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  4. Ram Mishra
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Corresponding author

Correspondence to Ashley Bernardo .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Bernardo, A., Prashar, S., Molinaro, L., Mishra, R. (2016). Synapsin II. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101863-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101863-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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