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High Molecular Weight Targets and Treatments Using Microdialysis

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Microdialysis in Drug Development

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 4))

Abstract

Advances in proteomics, the quest for biomarker discovery and the desire to understand drug mechanisms at the cellular level all require the ability to obtain relevant biological samples, preferably from humans. Microdialysis sampling is a well-established and widely accepted method for the in vivo collection of solutes, including high molecular weight compounds, from a number of complex matrices, but principally from the extracellular fluid space. Here, we summarize the current status of microdialysis sampling of high molecular weight targets which, together with novel analytical methodologies, can lead to a better understanding of the healthy tissue proteome and how this may be changed in disease. Further, the potential for microdialysis to be used to explore the penetration of high molecular weight drugs into the extravascular compartment and the mechanisms by which they exert their beneficial effects is considered.

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Authors and Affiliations

  1. Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, MP 887, Southampton, SO16 6YD, UK

    Geraldine F. Clough

  2. Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA

    Julie A. Stenken

  3. Charité Universitätsmedizin, Berlin, Germany

    Martin K. Church

Authors
  1. Geraldine F. Clough
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  2. Julie A. Stenken
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  3. Martin K. Church
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Corresponding author

Correspondence to Geraldine F. Clough .

Editor information

Editors and Affiliations

  1. Allgemeines Krankenhaus, Department of Clinical Pharmacology, Medical University Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria

    Markus Müller

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Clough, G.F., Stenken, J.A., Church, M.K. (2013). High Molecular Weight Targets and Treatments Using Microdialysis. In: Müller, M. (eds) Microdialysis in Drug Development. AAPS Advances in the Pharmaceutical Sciences Series, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4815-0_13

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