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GPR55 in the CNS

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endoCANNABINOIDS

Part of the book series: The Receptors ((REC,volume 24))

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Abstract

The identification of GPR55 as a possible cannabinoid receptor generated a flurry of interest as based on the hope that this receptor might explain some of the non-CB1/CB2/TRPV1 effects of cannabinoid compounds. However, it rapidly became clear that the pharmacology and signaling of GPR55 were quite complicated. Work over the last few years has found that lysophosphatidyl inositol is a major endogenous ligand for GPR55, with phytocannabinoids and endocannabinoids having a lesser role. This review briefly summarizes our current understanding of GPR55 signaling and its role in the central nervous system.

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Author information

Authors and Affiliations

  1. Department of Pediatrics and Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA

    Hui-Chen Lu

  2. Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA

    Jane E. Lauckner

  3. Department of Chemistry, Clemson University, Clemson, SC, USA

    John W. Huffman

  4. The Gill Center and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA

    Ken Mackie

Authors
  1. Hui-Chen Lu
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  2. Jane E. Lauckner
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  3. John W. Huffman
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  4. Ken Mackie
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Corresponding author

Correspondence to Ken Mackie .

Editor information

Editors and Affiliations

  1. , Anatomy and Cell Biology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, 19140, Pennsylvania, USA

    Mary E. Abood

  2. National Institutes of Health, Division of Basic Neuroscience and Behav, National Institute on Drug Abuse, 6001 Executive Blvd, Bethesda, 20892, Maryland, USA

    Roger G Sorensen

  3. , Pharmacology and Psychiatry and Behavior, University of Washington, Box 357280, Seattle, 98195, Washington, USA

    Nephi Stella

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Lu, HC., Lauckner, J.E., Huffman, J.W., Mackie, K. (2013). GPR55 in the CNS. In: Abood, M., Sorensen, R., Stella, N. (eds) endoCANNABINOIDS. The Receptors, vol 24. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4669-9_3

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