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Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 Infection

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Book cover HIV Interactions with Dendritic Cells

Part of the book series: Advances in Experimental Medicine and Biology ((volume 762))

Abstract

The main route of human immunodeficiency virus-1 (HIV-1) infection is via unprotected sexual intercourse, and therefore, vaginal tissues and male foreskin are viral entry sites. Langerhans cells (LCs) and dendritic cells (DCs) are amongst the first immune cells encountering HIV-1 since these cells line these mucosal tissues. Both LCs and DCs are equipped with specific pattern recognition receptors that not only sense pathogens, but induce specific immune responses against these pathogens. LCs express the C-type lectin receptor langerin, which provides protection against HIV-1 infection. In contrast, DCs express the C-type lectin receptor DC-SIGN, which facilitates capture as well as infection of DCs and subsequent transmission to CD4+ T cells. This chapter gives an update on immune responses elicited against viruses and sheds a light on different immune mechanisms that are hijacked by HIV-1 to infect the host. HIV-1 infection ultimately leads to the worldwide pandemic acquired immunodeficiency syndrome (AIDS).

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Acknowledgements

We thank the members of the Host Defense group for their valuable input. LMvdB is supported by the Dutch Burns Foundation (grant number 08.109) and TBHG is supported by the Dutch Scientific Research program (grant number NWO VICI 918.10.619).

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  1. Department of Experimental Immunology, Academic Medical Center (AMC), University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands

    Linda M. van den Berg M.Sc. & Teunis B. H. Geijtenbeek Ph.D.

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  1. Linda M. van den Berg M.Sc.
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  2. Teunis B. H. Geijtenbeek Ph.D.
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Correspondence to Teunis B. H. Geijtenbeek Ph.D. .

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  1. , Center for Retrovirus Research, The Ohio State University, 466 VMAB, 1900 Coffey Road, Columbus, 43210, Ohio, USA

    Li Wu

  2. , Department of Virology, Institut Pasteur, 28 rue du Dr Roux, Paris, 75724, France

    Olivier Schwartz

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© 2012 Springer Science+Business Media New York

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van den Berg, L.M., Geijtenbeek, T.B.H. (2012). Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 Infection. In: Wu, L., Schwartz, O. (eds) HIV Interactions with Dendritic Cells. Advances in Experimental Medicine and Biology, vol 762. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4433-6_2

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