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Pharmacological Treatment of Obesity

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Book cover Sleep Loss and Obesity

Abstract

Obesity is a chronic disease resulting in major morbidity and premature death globally. Current pharmacological treatments are not fully acceptable because of their poor safety and efficacy. Obesity is also associated with other serious complications such as diabetes mellitus, hypertension, hyperlipidemia, hypercholesterolemia, cardiovascular disease etc. Because of its complex nature there is a need for safe and efficacious long-term pharmacological treatment. One treatment approach is not sufficient to manage complex pathological circuitry of obesity. Recently, several novel targets have been proposed that control energy homeostasis and prevent obesity. Although, newer drugs are years away from clinical use, the hope for research investments made to date is translation into safe and effective pharmacological treatment in the future. The goal of this chapter is to describe the latest strategies of pharmacological treatment that are under development, which may finally be used in future.

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Notes

  1. 1.

     VIVUS announces positive results from two phase 3 studies; Obese patients on Qnexa achieve average weight loss up to 14.7% and significant improvements in comorbidities. Results of EQUIP and CONQUER phase 3 studies exceed FDA benchmarks for obesity treatments, demonstrate positive safety profile. September 2009.

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Authors and Affiliations

  1. Cincinnati Diabetes and Obesity Centre, Division of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA

    Dhiraj G. Kabra PhD, Uma D. Kabra MPharm, Matthias H. Tschöp MD & Susanna Hofmann MD

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  1. Dhiraj G. Kabra PhD
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Correspondence to Matthias H. Tschöp MD .

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  1. , Division of Sleep Medicine, Harvard Medical School, 1400 VFW Parkway, West Roxbury, 02132, USA

    Priyattam Shiromani

  2. , Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave., New Haven, 06519, USA

    Tamas Horvath

  3. , Department of Medicine, Harvard Medical School, Brigham and Wome, 221 Longwood Ave., Boston, 02115, USA

    Susan Redline

  4. , Department of Medicine, The University of Chicago, 5841 S. Maryland Avenue, Chicago, 60637, USA

    Eve Van Cauter

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Kabra, D.G., Kabra, U.D., Tschöp, M.H., Hofmann, S. (2012). Pharmacological Treatment of Obesity. In: Shiromani, P., Horvath, T., Redline, S., Van Cauter, E. (eds) Sleep Loss and Obesity. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3492-4_14

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