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Retinal Degenerative Diseases pp 77–83Cite as

Animal Models, in “The Quest to Decipher RPE Phagocytosis”

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 801))

Abstract

Renewal and elimination of aged photoreceptor outer segment (POS) tips by cells from the retinal pigment epithelial (RPE) is a daily rhythmic process that is crucial for long-term vision. Anomalies can arise during any of the sequential steps required for completion of this phagocytic function, from POS recognition to complete digestion of POS components. During the past 15 years, many animal models helped us characterize the molecular machinery implicated in RPE phagocytosis as well as understand associated defects leading to various retinal pathologies. Depending on which part of the machinery is flawed, phenotypes can either appear early in life, such as retinitis pigmentosa or Usher syndrome, or develop with aging of the individual, like age-related macular degeneration, affecting first either the peripheral or the central retina. This chapter describes mouse and rat models related to defective phagocytosis, and how they have been a tremendous help for us to comprehend RPE phagocytosis, its rhythm, and its failures.

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Author information

Authors and Affiliations

  1. INSERM, U968, 17 rue Moreau, 75012, Paris, France

    Emeline F. Nandrot

  2. Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, 17 rue Moreau, 75012, Paris, France

    Emeline F. Nandrot

  3. CNRS, UMR_7210, 17 rue Moreau, 75012, Paris, France

    Emeline F. Nandrot

Authors
  1. Emeline F. Nandrot
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Correspondence to Emeline F. Nandrot .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Florida, Gainesville, Florida, USA

    John D. Ash

  2. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  3. Cole Eye Institute at the Cleveland Clin Division of Ophthalmology, Cleveland, Ohio, USA

    Joe G. Hollyfield

  4. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  5. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  6. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

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Nandrot, E. (2014). Animal Models, in “The Quest to Decipher RPE Phagocytosis”. In: Ash, J., Grimm, C., Hollyfield, J., Anderson, R., LaVail, M., Bowes Rickman, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 801. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3209-8_10

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  • DOI: https://doi.org/10.1007/978-1-4614-3209-8_10

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3208-1

  • Online ISBN: 978-1-4614-3209-8

  • eBook Packages: MedicineMedicine (R0)

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