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Viral Molecular Machines pp 5–16Cite as

F1-ATPase: A Prototypical Rotary Molecular Motor

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 726))

Abstract

F1-ATPase, the soluble portion of ATP synthase, has been shown to be a rotary molecular motor in which the central γ subunit rotates inside the cylinder made of α3β3 subunits. The rotation is powered by ATP hydrolysis in three catalytic sites, and reverse rotation of the γ subunit by an external force leads to ATP synthesis in the catalytic sites. Here I look back how our lab became involved in the study of this marvelous rotary machine, and discuss some aspects of its rotary mechanism while confessing we are far from understanding. This article is a very personal essay, not a scientific review, for this otherwise viral machines book.

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Acknowledgments

I thank members of Kinosita and Yoshida labs for collaboration and discussion, R. Kanda-Terada for technical support, and S. Takahashi, K. Sakamaki, M. Fukatsu, and H. Umezawa for encouragement and lab management. This work was supported by Grants-in-Aids for Specially Promoted Research from the Ministry of Education, Sports, Culture, Science and Technology, Japan.

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Authors and Affiliations

  1. Department of Physics, Waseda University, Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan

    Kazuhiko Kinosita Jr.

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  1. Kazuhiko Kinosita Jr.
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Correspondence to Kazuhiko Kinosita Jr. .

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Editors and Affiliations

  1. Dept. Biological Sciences, Purdue University, W. State St. 915, West Lafayette, 47907-2054, Indiana, USA

    Michael G. Rossmann

  2. Dept. Biology, Catholic University of America, Washington, 20064, District of Columbia, USA

    Venigalla B. Rao

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Kinosita, K. (2012). F1-ATPase: A Prototypical Rotary Molecular Motor. In: Rossmann, M., Rao, V. (eds) Viral Molecular Machines. Advances in Experimental Medicine and Biology, vol 726. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0980-9_2

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