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Vitamin D Binding Proteins

  • Chapter
Advances in Nutritional Research

Part of the book series: Advances in Nutritional Research ((ANUR,volume 4))

Abstract

In recent years, considerable growth has occurred in our understanding of the distribution, metabolism, and action of antiricketic sterols. Vitamin D is recognized to be synthesized in the skin, absorbed from the intestine, and transformed to more potent bioactive metabolites. Whether derived from cutaneous transformation of 7-dehydrocholesterol or dietary sources, vitamin D enters the liver where it is metabolized to 25-hydroxyvitamin D (25-OHD) by microsomal (De-Luca and Schnoes, 1976) and/or mitrochondrial (Björkhem and Holmberg, 1978) hydroxylases. Subsequently, 25-OHD can be metabolized to an array of dihy-droxylated forms of vitamin D. The most potent of these sterols in calcium translocation at the intestine and skeleton is 1,25-dihydroxyvitamin D [1,25-(OH)2D], a product of kidney (Fraser and Kodicek, 1970) cell metabolism. The production of 1,25-(OH)2D is closely regulated, perhaps most strikingly by the trophic action of parathyroid hormone (Fraser and Kodicek, 1973). Other metabolites have been isolated arid identified, but their physiological significance awaits clarification (DeLuca, 1979).

The work in the author’s laboratory was supported in part by Career Development Award AM11674, Research Grant AM14570, and CRC Grant RR-00036 from the N.I.H.

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Abbreviations

DBP:

plasma binding protein for vitamin D and its metabolites

Gc:

group-specific component plasma protein

PAGE:

polyacrylamide gel electrophoresis

SDS:

sodium dodecylsulfate

25-OHD:

25-hydroxyvitamin D

24,25-(OH)2D:

24,25-dihydroxyvitamin D

1,25-(OH)2D:

1,25-dihydroxyvitamin D

25,26-(OH)2D:

25,26-dihydroxyvitamin D

DTT:

dithiothreitol

EDTA:

ethylene diaminetetraacetic acid

References

  • Avioli, L. V., Lee, S. W., McDonald, J. E., Lund, J., and DeLuca, H. F., 1967, Metabolism of vitamin D3 -3H in human subjects: Distribution in blood, bile, feces and urine, J. Clin. Invest. 46:983.

    Article  PubMed  CAS  Google Scholar 

  • Barragry, M. D., Carter, N. D., Beer, M., France, M. W., Anton, J. A., Boucher, B. J., and Cohen, R. D., 1977, Vitamin D metabolism in nephrotic syndrome, Lancet 2:629.

    Article  PubMed  CAS  Google Scholar 

  • Batchelet, M., Ulmann, A., Cloix, J. F., and Funck-Brentano, J. L., 1977, Nuclear uptake of cholecalciferol metabolites in rat duodenal mucosa, J. Steroid Biochem. 8:1047.

    Article  Google Scholar 

  • Baxter, J. D., and Funder, J. W., 1979, Hormone receptors, N. Engl. J. Med. 301:1149.

    Article  PubMed  CAS  Google Scholar 

  • Bayard, F., Bec, P., and Louvet, J. P., 1972, Measurement of plasma 25-hydroxycholecalciferol in man, Eur. J. Clin. Invest. 2:195.

    Article  PubMed  CAS  Google Scholar 

  • Bec, P., Bayard, F., and Louvet, J. P., 1972, 25-Hydroxycholecalciferol dynamics in human plasma, Rev. Eur. Etudes Clin. Biol. 17:793.

    CAS  Google Scholar 

  • Belsey, R. E., DeLuca, H. F., and Potts, J. T., Jr., 1974, Selective binding properties of vitamin D transport protein in chick plasma in vitro, Nature 247:208.

    Article  PubMed  CAS  Google Scholar 

  • Bills, C. E., 1935, Physiology of the sterols, including vitamin D, Physiol. Rev. 15:1.

    CAS  Google Scholar 

  • Bills, C. E., 1954, Chemistry of vitamin D group, in: The Vitamins (W. H. Sebrell Jr. and R. S. Harris, eds.), p. 132, Academic Press, New York.

    Google Scholar 

  • Björkhem, I., and Holmberg, I., 1978, Assay and properities of a mitochondrial 25-hydroxylase active on vitamin D3, J. Biol. Chem. 253:842.

    PubMed  Google Scholar 

  • Botham, K. M., Tanaka, Y., and DeLuca, H. F., 1974, 25-Hydroxyvitamin D3–1-hydroxylase. Inhibition in vitro by rat and pig tissues, Biochemistry 13:4961.

    Article  PubMed  CAS  Google Scholar 

  • Botham, K. M., Ghazarian, J. G., Kream, B. E., and DeLuca, H. F., 1976, Isolation of an inhibitor of 25-hydroxyvitamin D3-1-hydroxylase from rat serum, Biochemistry 15:10.

    Article  Google Scholar 

  • Bouillon, R., Van Baelen, H., and DeMoor, P., 1976a, The transport of vitamin D in the serum of primates, Biochem. J. 150:463.

    Google Scholar 

  • Bouillon, R., Van Baelen, H., Rombauts, W., and DeMoor, P., 1976b, The purification and characterization of the human-serum binding protein for the 25-hydroxycholecalciferol. Identity with group-specific component, Eur. J. Biochem. 66:285.

    Article  PubMed  CAS  Google Scholar 

  • Bouillon, R., Van Baelen, H., and DeMoor, P., 1977, The measurement of the vitamin D-binding protein in human serum, J. Clin. Endocrinol. Metab. 45:225.

    Article  PubMed  CAS  Google Scholar 

  • Bouillon, R., Van Baelen, H., Rombuts, W., and DeMoor, P., 1978a, The isolation and characterization of the vitamin D-binding protein from rat serum, J. Biol. Chem. 253:4426.

    PubMed  CAS  Google Scholar 

  • Bouillon, R., Vandoren, G., Van Baelen, H., and DeMoor, P., 1978b, Immunochemical measurement of the vitamin D-binding protein rat serum, Endocrinology 102:1710.

    Article  PubMed  CAS  Google Scholar 

  • Bowman, B. H., and Beam, A. G., 1965, The presence of subunits in the inherited group-specific protein of human serum, Proc. Natl. Acad. Sci. U.S.A. 53:722.

    Article  PubMed  CAS  Google Scholar 

  • Brumbaugh, P. F., and Haussier, M. R., 1974a, 1α,25-Dihydroxycholecalciferol receptors in intestine. I. Association of 1α,25-dihydroxycholecalciferol with intestinal mucosa chromatin, J. Biol. Chem. 249:1251.

    PubMed  CAS  Google Scholar 

  • Brumbaugh, P. F., and Haussier, M. R., 1974b, 1α,25-Dihydroxycholecalciferol receptors in intestine. II. Temperature-dependent transfer of the hormone to chromatin via a specific cytosol receptor, J. Biol. Chem. 249:1258.

    PubMed  CAS  Google Scholar 

  • Brumbaugh, P. F., Haussier, D. H., Bressler, R., and Haussier, M. R., 1974, Radioreceptor assay for 1α-25-dihydroxyvitamin D3, Science 183:1089.

    Article  PubMed  CAS  Google Scholar 

  • Brumbaugh, P. F., Hughes, M. R., and Haussier, M. R., 1975, Cytoplasmic and nuclear binding components for 1α,25-dihydroxyvitamin D3 in chick parathyroid glands, Proc. Natl. Acad. Sci. U.S.A. 72:4871.

    Article  PubMed  CAS  Google Scholar 

  • Chen, P. S., Jr., and Lane, K., 1965, Serum protein binding of vitamin D3, Arch. Biochem. Biophys. 112:70.

    Article  PubMed  CAS  Google Scholar 

  • Chen, T. C., and DeLuca, H. F., 1973, Receptors of 1,25-dihydroxycholecalciferol in rat intestine, J. Biol. Chem. 248:4890.

    PubMed  CAS  Google Scholar 

  • Chen, T. C., Weber, J. C., and DeLuca, H. F., 1970, On the subcellular location of vitamin D metabolites in intestine, J. Biol. Chem. 245:3776.

    PubMed  CAS  Google Scholar 

  • Chertow, B. S., Baylink, D. J., Wergedal, J. E., Su, M. H. H., and Norman, A. W., 1975, Decrease in serum immunoreactive parathyroid hormone in rats and in parathyroid hormone secretion in vitro by 1,25-dihydroxycholecalciferol, J. Clin. Invest. 56:668.

    Article  PubMed  CAS  Google Scholar 

  • Christakos, S., and Norman, A. W., 1979, Studies on the mode of action of calciferol XVIII. Evidence for a specific high-affinity binding protein for 1,25-dihydroxyvitamin D3 in chick kidney and pancreas, Biochem. Biophys. Res. Commun. 89:56.

    Article  PubMed  CAS  Google Scholar 

  • Cleve, H., 1973, The variants of the group-specific component: A review of their distribution in human populations, Israel J. Med. Sci. 9:1133.

    PubMed  CAS  Google Scholar 

  • Cleve, H., and Patutschnick, W., 1979, Neuraminidase treatment reveals sialic acid differences in certain genetic variants of the Gc system (vitamin D-binding protein), Hum. Genet. 47:193.

    Article  PubMed  CAS  Google Scholar 

  • Cleve, H., Prunier, J. H., and Beam, A. G., 1963, Isolation and partial characterization of the two principal inherited group-specific components of human serum, J. Exp. Med. 118:711.

    Article  PubMed  CAS  Google Scholar 

  • Colston, K. W., and Feldman, D., 1979, Demonstration of a 1,25-dihydroxycholecalciferol cytoplasmic receptor-like binder in mouse kidney, J. Clin. Endocrinol. Metab. 49:798.

    Article  PubMed  CAS  Google Scholar 

  • Cooke, N. E., Walgate, J., and Haddad, J. G., 1979a, Human serum binding protein for vitamin D and its metabolites I. Physiochemical and immunological identification in human tissues, J. Biol. Chem. 254:5958.

    PubMed  CAS  Google Scholar 

  • Cooke, N. E., Walgate, J., and Haddad, J. G., 1979b, Human serum binding protein for vitamin D and its metabolites II. Specific, high-affinity association with a protein in nucleat-d tissue, J. Biol. Chem. 254:5965.

    PubMed  CAS  Google Scholar 

  • Corradino, R. A., 1976, Embryonic chick intestine organ culture: Earliest action of 1,25-(OH)2D3 is the stimulation of cyclic AMP production, Fed. Proc. 35:339.

    Google Scholar 

  • Daiger, S. P., 1976, The genetics of Transport Proteins in Human Plasma and Serum, Ph.D. Thesis, Stanford University, Stanford.

    Google Scholar 

  • Daiger, S. P., and Cavalli-Sforza, L. L., 1977, Detection of genetic variation with radioactive ligands. II. Genetic variants of vitamin D-labelled group-specific component (Gc) proteins, Am. J. Hum. Genet. 29:593.

    PubMed  CAS  Google Scholar 

  • Daiger, S. P., Schanfield, M. S., and Cavalli-Sforza, L. L., 1975, Group specific components (Gc) proteins bind vitamin D and 25-hydroxyvitamin D, Proc. Natl. Acad. Sci. U.S.A. 72:2076.

    Article  PubMed  CAS  Google Scholar 

  • DeCrousaz, P., Blanc, B., and Antener, I., 1965, Vitamin D activity in normal human serum and serum proteins, Helv. Odontol. Acta 9:151.

    CAS  Google Scholar 

  • DeLuca, H. F., 1979, Recent advances in our understanding of the vitamin D endocrine system, J. Steroid Biochem. 11:35.

    Article  PubMed  CAS  Google Scholar 

  • DeLuca, H. F., and Schnoes, H. K., 1976, Metabolism and mechanisms of action of vitamin D, Annu. Rev. Biochem. 45:631.

    Article  PubMed  CAS  Google Scholar 

  • Edelstein, S., 1974, Vitamin D-binding proteins, Biochem. Soc. Spec. Publ. 3:43.

    CAS  Google Scholar 

  • Edelstein, S., Lawson, D. E. M., and Kodicek, E., 1973, The transporting proteins of cholecalciferol and 25-hydroxycholecalciferol in serum of chick and other species, Biochem. J. 135:417.

    PubMed  CAS  Google Scholar 

  • Edelstein, S., Charman, M., Lawson, D. E. M., and Kodicek, E., 1974, Competitive proteinbinding assay for 25-hydroxycholecalciferol, Clin. Sci. Mol. Med. 46:231.

    PubMed  CAS  Google Scholar 

  • Eisman, J. A., and DeLuca, H. F., 1977, Intestinal 1,25-dihydroxyvitamin D3 binding protein: Specificity of binding, Steroids 30:245.

    Article  PubMed  CAS  Google Scholar 

  • Eisman, J. A., Haustra, A. J., Kream, B. E., and DeLuca, H. F., 1976, A sensitive, precise and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma, Arch. Biochem. Biophys. 176:235.

    Article  PubMed  CAS  Google Scholar 

  • Fraser, D. R., and Emtage, J. S., 1976, Vitamin D in the avian egg. Its molecular identity and mechanisms of incorporation into yolk, Biochem. J. 160:671.

    PubMed  CAS  Google Scholar 

  • Fraser, D. R., and Kodicek, E., 1970, Unique biosynthesis by kidney of a biologically active vitamin D metabolite, Nature 228:764.

    Article  PubMed  CAS  Google Scholar 

  • Fraser, D. R., and Kodicek, E., 1973, Regulation of 25-hydroxycholecalciferol 1-hydroxylase activity in kidney by parathyroid hormone, Nature [New Biol.] 241:163.

    CAS  Google Scholar 

  • Ghazarian, J. G., Hsu, P.-Y., Gviotti, A. W., and Winkelhake, J. L., 1978a, Purification of calciferol-binding proteins from kidney: Physicochemical and immunological properties, J. Lipid Res. 19:601.

    PubMed  CAS  Google Scholar 

  • Ghazarian, J. G., Kream, B., Botham, K. M., Mickells, M., and DeLuca, H. F., 1978b, Rat plasma 25-hydroxyvitamin D3 binding protein: An inhibitor of the 25-hydroxyvitamin D3–1/-hydroxylase, Arch. Biochem. Biophys. 189:212.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, J. L., and Brown, M. S., 1976, The LDL pathway in human fibroblasts: A receptor-mediated mechanisms for the regulation of cholesterol metabolism, Curr. Top. Cell. Regul. 11:147.

    PubMed  CAS  Google Scholar 

  • Goldstein, J. L., Anderson, R. G. W., and Brown, M. S., 1979, Coated pits, coated vesicles, and receptor-mediated endocytosis, Nature 279:679.

    Article  PubMed  CAS  Google Scholar 

  • Gray, R. W., Caldas, A. E., Wilz, D. R., Lemann, J., Jr., Smith, G. A., and DeLuca, H. F., 1978, Metabolism and excretion of 3H-1,25-(OH)2-vitamin D3 in healthy adults, J. Clin. Endocrinol. Metab. 46:756.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., 1979, Transport of vitamin D metabolites, Clin. Orthop. 142:249.

    PubMed  CAS  Google Scholar 

  • Haddad, J. G., 1980, Purification, characterization and quantitation of the human serum binding protein for vitamin D and its metabolites, Methods Enzymol. 67:449.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., and Birge, S. J., 1971, 25-Hydroxycholecalciferol: Specific binding by ricketic tissue extracts, Biochem. Biophys. Res. Commun. 45:829.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., and Birge, S. J., 1975, Widespread, specific binding of 25-hydroxycholecalciferol in rat tissues, J. Biol. Chem. 250:299.

    PubMed  CAS  Google Scholar 

  • Haddad, J. G., and Chyu, K. J., 1971a, 25-Hydroxycholecalciferol-binding globulin in human plasma, Biochim. Biophys. Acta 248:471.

    Article  CAS  Google Scholar 

  • Haddad, J. G., and Chyu, K. J., 1971b, Competitive protein binding radioassay for 25-hydroxycholecalciferol, J. Clin. Endocrinol. Metab. 33:992.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., and Stamp, T. C. B., 1974, Circulating 25-hydroxyvitamin D in man, Am. J. Med. 57:57.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., and Walgate, J., 1976a, 25-Hydroxyvitamin D transport in human plasma. Isolation and partial characterization of calcifidiol-binding protein, J. Biol. Chem. 251:4803.

    PubMed  CAS  Google Scholar 

  • Haddad, J. G., and Walgate, J., 1976b, Radioimmunoassay of the binding protein for vitamin D and its metabolites in human serum. Concentrations in normal subjects and patients with disorders of mineral homeostasis, J. Clin. Invest. 58:1217.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., Birge, S. J., and Hahn, T. J., 1973a, Vitamin D metabolites: Specific binding by rat intestinal cytosol, Biochim. Biophys. Acta 329:93.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., Chyu, K. J., Hahn, T. J., and Stamp, T. C. B., 1973b, Serum concentrations of 25-hydroxyvitamin D in sex-linked hypophysphatemic vitamin D-resistant rickets, J. Lab. Clin. Med. 81:22.

    PubMed  Google Scholar 

  • Haddad, J. G., Walgate, J., Min, C., and Hahn, T. J., 1976a, Vitamin D metabolite-binding proteins in human tissue, Biochim. Biophys. Acta 444:921.

    Article  PubMed  CAS  Google Scholar 

  • Haddad, J. G., Hillman, L., and Rojanasathit, S., 1976b, Human serum binding capacity and affinity for 25-hydroxyergocalciferol and 25-hydroxycholecalciferol, J. Clin. Endocrinol. Metab. 43:86.

    Article  PubMed  CAS  Google Scholar 

  • Haussier, M. R., and McCain, T. A., 1977, Basic and clinical concepts related to vitamin D metabolism and action, N. Engl. J. Med. 297:974, 1041.

    Article  Google Scholar 

  • Haussier, M. R., Nagode, L. A., and Rasmussen, H., 1970, Induction of intestinal brush border alkaline phosphatase by vitamin D and identity with Ca-ATPase, Nature 228:1199.

    Article  Google Scholar 

  • Hay, A. W. M., 1975, The transport of 25-hydroxycholecalciferol in a New World monkey, Biochem. J. 151:193.

    PubMed  CAS  Google Scholar 

  • Hay, A. W. M., and Watson, G., 1976a, The plasma transport proteins of 25-hydroxycholecalciferol in mammals, Comp. Biochem. Physiol. 53B:163.

    Google Scholar 

  • Hay, A. W. M., and Watson, G., 1976b, The plasma transport proteins of 25-hydroxycholecalciferol in fish, amphibians, reptiles and birds, Comp. Biochem. Physiol. 53B.167.

    Google Scholar 

  • Heimburger, N., Heide, K., Haupt, H., and Schultze, H. E., 1964, Baustein Analysen von human serum Proteinen, Clin. Chim. Acta 10:293.

    Article  PubMed  CAS  Google Scholar 

  • Heller, J., 1975, Interactions of plasma retinol-binding protein with its receptor, J. Biol. Chem. 250:3613.

    PubMed  CAS  Google Scholar 

  • Hirschfield, J., 1959, Immunoelectrophoretic demonstration of quantitative differences in human sera and their relation to the hepatoglobins, Acta Pathol. Microbiol. Scand. 47:160.

    Article  Google Scholar 

  • Horst, R. L., 1979, 25-OHD3–26,23-Lactone: A metabolite of vitamin D3 that is 5 times more potent than 25-OHD3 in the rat plasma competitive protein binding radioassay, Biochem. Biophys. Res. Commun. 89:286.

    Article  PubMed  CAS  Google Scholar 

  • Hughes, M. R., and Haussier, M. R., 1978, 1,25-Dihydroxyvitamin D3 receptors in parathyroid glands. Preliminary characterization of cytoplasmic and nuclear binding components, J. Biol. Chem. 253:1065.

    PubMed  CAS  Google Scholar 

  • Hughes, M. R., Baylink, D. J., Hones, P. G., and Haussier, M. R., 1976, Radiology and receptor assay for 25-hydroxyvitamin D2/D3 and 1,25-dihydroxyvitamin D2/D3, J. Clin. Invest. 58:61.

    Article  PubMed  CAS  Google Scholar 

  • Imawari, M., and Goodman, D. S., 1977, Immunological and immunoassay studies of the binding protein for vitamin D and its metabolites in human serum, J. Clin. Invest. 59:432.

    Article  PubMed  CAS  Google Scholar 

  • Imawari, M., Kida, K., and Goodman, D. S., 1976, The transport of vitamin D and its 25-hydroxy metabolite in human plasma, J. Clin. Invest. 58:514.

    Article  PubMed  CAS  Google Scholar 

  • Imawari, M., Akanuma, Y., Itakura, H., Muto, Y., Kasaka, K., and Goodman, D. S., 1979, The effects of diseases of the liver on serum 25-hydroxyvitamin D and on the serum binding protein for vitamin D and its metabolites, J. Lab. Clin. Med. 93:171.

    PubMed  CAS  Google Scholar 

  • Jacobs, R. L., and Ray, R. D., 1968, Studies of vitamin D binding in normal and rachitic serum, Clin. Orthop. 56:275.

    PubMed  CAS  Google Scholar 

  • Kawakami, M., Imawari, M., and Goodman, D. S., 1979, Quantitative studies of the interaction of cholecalciferol and its metabolites with different genetic variants of the serum binding protein for these sterols, Biochem. J. 179:413.

    PubMed  CAS  Google Scholar 

  • Kitchin, F. D., and Beam, A. G., 1965, Quantitative determination of the group specific protein in normal human serum, Proc. Soc. Exp. Biol. Med. 118:304.

    PubMed  CAS  Google Scholar 

  • Kream, B. E., Reynolds, R. D., Knutson, J. C., Eisman, J. A., and DeLuca, H. F., 1976, Etestinal cytosol binders of 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D, Arch. Biochem. Biophys. 176:779.

    Article  PubMed  CAS  Google Scholar 

  • Kream, B. E., Jose, M. J. L., and DeLuca, H. F., 1977a, The chick intestinal cytosol binding protein for 1,25-dihydroxyvitamin D3: A study of analog binding, Arch. Biochem. Biophys. 179:462.

    Article  PubMed  CAS  Google Scholar 

  • Kream, B. E., Jose, M., Yamada, S., and DeLuca, H. F., 1977b, A specific high-affinity binding macromolecule for 1,25-dihydroxyvitamin D3 in fetal bone, Science 197:1086.

    Article  PubMed  CAS  Google Scholar 

  • Kream, B. E., Yamada, S., Schnoes, H. K., and DeLuca, H. F., 1977c, Specific cytosol-binding protein for 1,25-dihydroxyvitamin D3 in rat intestine, J. Biol. Chem. 252:4501.

    PubMed  CAS  Google Scholar 

  • Kream, B. E., DeLuca, H. F., Moriarity, D. M., Kendrick, N. C., and Ghazarian, J. G., 1979, Origin of 25-hydroxyvitamin D3 binding protein from tissue cytosol preparations, Arch. Biochem. Biophys. 192:318.

    Article  PubMed  CAS  Google Scholar 

  • Lawson, D. E. M., and Wilson, P. W., 1974, Intranuclear localization and receptor proteins for 1,25-dihydroxycholecalciferol in chick intestine, Biochem. J. 144:573.

    PubMed  CAS  Google Scholar 

  • Lawson, D. E. M., Charman, M., Wilson, P. W., and Edelstein, S., 1976, Some characteristics of new tissue-binding proteins for metabolites of vitamin D other than 1,25-dihydroxyvitamin D, Biochim. Biophys. Acta 437:403.

    Article  PubMed  CAS  Google Scholar 

  • Manalagos, S. C., Taylor, C. M., and Anderson, D. C., 1979, Highly specific binding of 1,25-dihydroxycholecalciferol in bone cytosol, J. Endocrinol. 80:35.

    Article  Google Scholar 

  • Mawer, E. B., Backhouse, J., Holman, C. A., Lumb, G. A., and Stanbury, S. W., 1972, The distribution and storage of vitamin D and its metabolites in human tissues, Clin. Sci. 43:413.

    PubMed  CAS  Google Scholar 

  • Mawer, E. B., Backhouse, J., Davies, M., Hill, J. L., and Taylor, C. M., 1976, Metabolic fate of administered 1,25-dihydroxycholecalciferol in controls and patients with hypoparathyroidism, Lancet 1:1203.

    Article  PubMed  CAS  Google Scholar 

  • McCain, T. A., Haussier, M. R., Okrent, D., and Huges, M. R., 1978, Partial purification of the chick intestinal receptor for 1,25-dihydroxyvitamin D by ion exchange and blue dextran-sepharose chromatography, FEBS Let. 86:65.

    Article  CAS  Google Scholar 

  • Melancon, M. J., Jr., and DeLuca, H. F., 1970, Vitamin D stimulation of calcium-dependent adenosive triphosphatase in chick intestinal brush borders, Biochemistry 9:1658.

    Article  PubMed  CAS  Google Scholar 

  • Mellon, W. S., and DeLuca, H. F., 1979, An equilibrium and kinetic study of 1,25-dihydroxyvitamin D3 binding to chicken intestinal cytosol employing high specific activity 1,25-dihydroxy|3H-26,27}vitamin D3, Arch. Biochem. Biophys. 197:90.

    Article  PubMed  CAS  Google Scholar 

  • Nahm, T. H., Lee, S. W., Fausto, A., Sonn, Y., and Avioli, L. V., 1979, 25-OHD, a circulating vitamin D metabolite in fish, Biochem. Biophys. Res. Commun. 89:396.

    Article  PubMed  CAS  Google Scholar 

  • Napoli, J. L., Fivizzani, M. A., Hamstra, A. J., Schnoes, H. K., and DeLuca, H. F., 1979, Synthesis of 25-hydroxy|26,27-3}Hvitamin D3 with high specific activity, Anal. Biochem. 96:481.

    Article  PubMed  CAS  Google Scholar 

  • Norman, A. W., and DeLuca, H. F., 1963, The preparation of 3H-vitamins D2 and D3 and their localization in the rat, Biochemistry 2:1160.

    Article  PubMed  CAS  Google Scholar 

  • Oku, T., Ooizumi, K., and Hosoya, N., 1974, Binding proteins for 1,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol, J. Nutr. Sci. Vitaminol. 20:9.

    Article  PubMed  CAS  Google Scholar 

  • Omdahl, J. L., and DeLuca, H. F., 1973, Regulation of Vitamin D metabolism and function, Physiol. Rev. 53:327.

    PubMed  CAS  Google Scholar 

  • Peterson, P. A., 1971, Isolation and partial characterization of a human vitamin D-binding plasma protein, J. Biol. Chem. 246:7748.

    PubMed  CAS  Google Scholar 

  • Preece, M. A., O’Riordan, J. L. H., Lawson, D. E. M., and Kodicek, E., 1974, A competitive protein binding assay for 25-hydroxycholecalciferol and 25-hydroxyergocalciferol in serum, Clin. Chem. Acta 54:235.

    Article  CAS  Google Scholar 

  • Rikkers, H., and DeLuca, H. F., 1967, An in vivo study of the carrier proteins of 3H-vitamins D3 and D4 in rat serum, Am. J. Physiol. 213:380.

    PubMed  CAS  Google Scholar 

  • Rikkers, H., Kletziens, R., and DeLuca, H. F., 1969, Vitamin D binding globulin in the rat: Specificity for the vitamins D, Proc. Soc. Exp. Biol. Med. 130:1321.

    PubMed  CAS  Google Scholar 

  • Rojanasathit, S., and Haddad, J. G., 1977, Ontogeny and effect of vitamin D deprivation on rat serum 25-hydroxyvitamin D binding protein, Endocrinology 100:642.

    Article  PubMed  CAS  Google Scholar 

  • Rosenstreich, S. J., Rich, C., and Volwiler, W., 1971a, Deposition in and release of vitamin D3 from body fat: Evidence for a storage site in the rat, J. Clin. Invest. 50:679.

    Article  PubMed  CAS  Google Scholar 

  • Rosenstreich, S. J., Volwiler, W., and Rich, C., 1971b, Metabolism and plasma protein transport of vitamin D3 in the baboon, Am. J. Clin. Nutr. 24:897.

    PubMed  CAS  Google Scholar 

  • Schmidt-Gayk, H., Grawunder, C., Tschope, W., Schmitt, W., Ritz, E., Dietsch, V., Andrassy, K., and Bouillon, R., 1977, 25-Hydroxyvitamin D in nephrotic syndrome, Lancet 2:105.

    Article  PubMed  CAS  Google Scholar 

  • Shepard, R. M., Horst, R. L., Hamstra, A. J., and DeLuca, H. F., 1979, Determination of vitamin D and its metabolites in plasma from normal and anephric man, Biochem. J. 182:55.

    PubMed  CAS  Google Scholar 

  • Shimura, F., Moriuchi, S., and Hosoya, N., 1977, Some characteristics of cytosol-binding protein for 1/,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol in rat intestinal mucosa, J. Nutri. Sci. Vitaminol. 23:187.

    Article  CAS  Google Scholar 

  • Silver, J., Shvil, Y., and Fainaru, M., 1978, Vitamin D transport in an infant with vitamin D toxicity, B. Med. J. 2:93.

    Article  CAS  Google Scholar 

  • Simons, K., and Beam, A. G., 1967, The use of preparative Polyacrylamide column electrophoresis in isolation of electrophoretically distinguishable components of the serum group-specific protein, Biochem. Biophys. Acta 133:499.

    Article  PubMed  CAS  Google Scholar 

  • Smith, F. R., Raz, A., and Goodman, D. S., 1970, Radioimmunoassay of human plasma retinol-binding protein, J. Clin. Invest. 49:1754.

    Article  PubMed  CAS  Google Scholar 

  • Smith, J. E., and Goodman, D. S., 1971, The turnover and transport of vitamin D and of a polar metabolite with the properties of 25-hydroxycholecalciferol in human plasma, J. Clin. Invest. 50:2159.

    Article  PubMed  CAS  Google Scholar 

  • Spencer, R., Charman, M., Emtage, J. S., and Lawson, D. E. M., 1976, Production and properties of vitamin D-induced mRNA for chick calcium-binding protein, Eur. J. Biochem. 71:399.

    Article  PubMed  CAS  Google Scholar 

  • Svasti, J., and Bowman, B. H., 1978, Human group-specific component, J. Biol. Chem. 253:4188.

    PubMed  CAS  Google Scholar 

  • Thomas, W. C., Morgan, H. F., Connar, T. B., Haddock, L., Bills, C. E., and Howard, J. E., 1959, Studies of antiricketic activity in sera from patients with disorders of calcium metabolism and preliminary observations in the mode of transport by vitamin D in human serum, J. Clin. Invest. 38:1078.

    Article  PubMed  CAS  Google Scholar 

  • Tsai, H. C., and Norman, A. W., 1973, Studies on calciferol metabolism VIII. Evidence for a cytoplasmic receptor for 1,25-dihydroxyvitamin D3 in the intestinal mucosa, J. Biol. Chem. 248:5967.

    PubMed  CAS  Google Scholar 

  • Tsai, H. C., Wong, R. C., and Norman, A. W., 1972, Studies on calciferol metabolism. IV. Subcellular localization of 1,25-dihydroxyvitamin D3 in intestinal mucosa and correlation with increased calcium transport, J. Biol. Chem. 247:5511.

    PubMed  CAS  Google Scholar 

  • Ulmann, A., Brami, M., Pezant, E., Garabedian, M., and Funck-Bretano, J. L., 1977, Binding of cholecalciferol metabolites to rat duodenal mucosa cytosol, Acta Endocrinol. (Kbh.) 84:439.

    CAS  Google Scholar 

  • Van Baelen, H., Bouillon, R., and DeMoor, P., 1977, Binding of 25-hydroxycholecalciferol in tissues, J. Biol. Chem. 252:2515.

    PubMed  Google Scholar 

  • Van Baelen, H., Bouillon, R., and DeMoor, P., 1978, The heterogeneity of human Gc-globulin, J. Biol. Chem. 253:6344.

    PubMed  Google Scholar 

  • Wasserman, R. H., and Feber, J. J., 1977, Vitamin D-dependent calcium binding proteins, in: Calcium-Binding Proteins and Calcium Function (R. H. Wasserman, R. A. Corradino, E. Carafoli, R. H. Kretsinger, D. H. MacLennan, and S. L. Siegel, eds.), p. 292, Elsevier-North-Holland, Amsterdam.

    Google Scholar 

  • Weber, J. C., Pons, V., and Kodicek, E., 1971, The localization of 1,25-dihydroxycholecalciferol in bone cell nuclei of rachitic chicks, Biochem. J. 125:147.

    PubMed  CAS  Google Scholar 

  • Wecksler, W. R., Mason, R. S., and Norman, A. W., 1979, Specific cytosol receptors for 1,25-dihydroxyvitamin D3 in human intestine, J. Clin. Endocrinol. Metab. 48:715.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, P. W., and Lawson, D. E. M., 1977, 1,25-Dihydroxyvitamin D stimulation of specific membrane proteins in chick intestine, Biochim. Biophys. Acta 497:805.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, K. R., and Alberts, B. M., 1976, Steroid receptors: Elements for modulation of eukaryotic transcription, Annu. Rev. Biochem. 45:932.

    Article  Google Scholar 

  • Zerwekh, J. E., Haussier, M. R., and Lindell, T. J., 1974, Rapid enhancement of chick intestinal DNA-dependent RNA polymerase II activity by 1/,25-dihydroxyvitamin D3 in vivo, Proc. Natl. Acad. Sci. U.S.A. 71:2337.

    Article  CAS  Google Scholar 

  • Zerwekh, J. E., Lindell, T. J., and Haussier, M. R., 1976, Increased intestinal chromatin template activity influence of 1,25-Dihydroxyvitamin D3 and hormone-receptor complexes, J. Biol. Chem. 251:2388.

    PubMed  CAS  Google Scholar 

  • Zile, M., Bunge, E. C., Barsness, L., Yamada, S., Schnoes, H. F., and DeLuca, H. F., 1978, Localization of 1,25-Dihydroxyvitamin D in intestinal nuclei in vivo, Arch. Biochem. Biophys. 186:15.

    Article  PubMed  CAS  Google Scholar 

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  1. Endocrine Division, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, 19104, USA

    John G. Haddad Jr.

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  1. University of Guelph, Guelph, Ontario, Canada

    Harold H. Draper

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© 1982 Plenum Press, New York

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Haddad, J.G. (1982). Vitamin D Binding Proteins. In: Draper, H.H. (eds) Advances in Nutritional Research. Advances in Nutritional Research, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-9934-6_2

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  • DOI: https://doi.org/10.1007/978-1-4613-9934-6_2

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