Abstract
Treatment of BALB/c mice with high dose fractionated total lymphoid irradiation (TLI) allows for the engraftment of allogeneic bone marrow (BM) without the subsequent development of graft vs. host disease (GVHD) (1–3). The resultant chimeras are specifically tolerant to tissues of the marrow donor strain, and reject third-party allografts (1–3). The mechanism and cellular basis of the induction and maintenance of tolerance and lack of GVHD in the chimeras is not clear. However, studies of mice treated with TLI and tolerized to bovine serum albumin (BSA) or bovine gamma globulin (BGG) show that specific suppressor T cells are involved in the maintenance of tolerance to the heterologous proteins (4).
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References
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© 1985 Plenum Press, New York
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Slavin, S., Weigensberg, M., Bar, S., Weiss, L., Morecki, S. (1985). The Role of Suppresor T Lymphocytes in the Maintenance of Tolerance to Alloantigens in Bone Marrow Chimeras Prepared with Total Lymphoid Irradiation (TLI). In: Klaus, G.G.B. (eds) Microenvironments in the Lymphoid System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2463-8_62
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DOI: https://doi.org/10.1007/978-1-4613-2463-8_62
Publisher Name: Springer, Boston, MA
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