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Interleukin-3 and its receptor

  • Chapter
Cytokines: Interleukins and Their Receptors

Part of the book series: Cancer Treatment and Research ((CTAR,volume 80))

Abstract

Cytokines are actively involved in the host-defense system to coordinate the functional activity and the generation of effector cells. Some of these molecules function as inflammatory mediators and hematopoietic growth factors at the same time such as IL-1, IL-6, IL-3, IL-5, and GM-CSF. While the former ubiquitously produced factors are involved in basic inflammatory reactions, the T-cell lymphokines help to recruit the non-specific effector system and to direct it to specific targets [1], Among these, IL-3 (or multi-CSF) is known as a pleiotropic cytokine with a broad spectrum of target cells and functions. This article summarizes relevant data about this molecule that has been the topic of several recent review articles [2–5].

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  1. Albrecht Lindemann
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  2. Roland Mertelsmann
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  1. Department of Bioimmunotherapy, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., Box 302, 77030, Houston, Texas, USA

    Razelle Kurzrock M.D.  & Moshe Talpaz M.D.  & 

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Lindemann, A., Mertelsmann, R. (1995). Interleukin-3 and its receptor. In: Kurzrock, R., Talpaz, M. (eds) Cytokines: Interleukins and Their Receptors. Cancer Treatment and Research, vol 80. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1241-3_5

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