Abstract
The first immunotoxins (ITs) assembled by Moolten et al. in the seventies [1, 2] were composed of antibodies linked to whole toxins such as diphtheria toxin and ricin. In order to circumvent the nonspecific binding due to the B chains, ITs with the A chain subunit of the polypeptide toxin ricin were constructed [3–11].
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© 1988 Kluwer Academic Publishers
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Jansen, F.K. et al. (1988). Toxin selection and modification: Utilization of the A chain of ricin. In: Frankel, A.E. (eds) Immunotoxins. Cancer Treatment and Research, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1083-9_7
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DOI: https://doi.org/10.1007/978-1-4613-1083-9_7
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