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The Effect of Cytochrome P-450-Dependent Metabolism and Other Enzyme Activities on Olfaction

  • Chapter
Molecular Neurobiology of the Olfactory System

Abstract

The scientific fields of inhalation toxicology, foreign compound metabolism, and olfactory physiology share broad interests in the interaction of foreign materials with biological systems. Inhalation toxicologists and olfactory physiologists share a narrower common interest in the effects of foreign compounds on nasal tissues. Inhalation toxicologists are interested in toxic effects, and olfactory physiologists concern themselves with stimulation to produce an olfactory response. The third field to be included here, that concerned with foreign compound metabolism, has until recently been of little interest to inhalation toxicologists (and that interest largely confined to the metabolism of inhaled compounds in the lung and liver) and has been of even less concern to olfactory physiologists. But, the increasing frequency with which nasal cancers and other lesions have been reported in laboratory animals exposed to toxicants by inhalation has led to increased research into the response of nasal tissue to inhaled materials. One recent finding is that the nasal tissues have high concentrations of enzymes that metabolize xenobiotics (Dahl, 1985a-c).

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Author information

Authors and Affiliations

  1. Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, 87185, New Mexico, USA

    Alan R. Dahl

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  1. Alan R. Dahl
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Editors and Affiliations

  1. Roche Institute of Molecular Biology, Nutley, New Jersey, USA

    Frank L. Margolis

  2. Wayne State University School of Medicine, Detroit, Michigan, USA

    Thomas V. Getchell

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© 1988 Plenum Press, New York

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Dahl, A.R. (1988). The Effect of Cytochrome P-450-Dependent Metabolism and Other Enzyme Activities on Olfaction. In: Margolis, F.L., Getchell, T.V. (eds) Molecular Neurobiology of the Olfactory System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0989-5_3

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  • DOI: https://doi.org/10.1007/978-1-4613-0989-5_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8280-8

  • Online ISBN: 978-1-4613-0989-5

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