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Free Radicals and Mitochondria Dysfunction in Excitotoxicity and Neurodegenerative Disease

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Cell Death and Diseases of the Nervous System

Abstract

The study of neurodegenerative diseases has begun converging with the previously disparate fields of free radical pathophysiology, excitotoxin-mediated neuronal death and mitochondrial physiology. This convergence has been prompted by increasing evidence that excitatory amino acids and free radical toxicity contribute to neuronal apoptosis (1) and to the etiology of chronic neurodegenerative diseases (2–12). Moreover, a growing body of evidence implicates mitochondrial energetic and oxidative dysfunction, due to congenital genetic defects, and perhaps to radical-induced mutations and oxidative enzyme impairment, in several neurodegenerative disorders (reviewed by [5,6,13–17]).

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Authors
  1. James A. Dykens
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Editors and Affiliations

  1. The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Vassilis E. Koliatsos MD

  2. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

    Rajiv R. Ratan MD, PhD

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Dykens, J.A. (1999). Free Radicals and Mitochondria Dysfunction in Excitotoxicity and Neurodegenerative Disease. In: Koliatsos, V.E., Ratan, R.R. (eds) Cell Death and Diseases of the Nervous System. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1602-5_3

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  • DOI: https://doi.org/10.1007/978-1-4612-1602-5_3

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-7213-7

  • Online ISBN: 978-1-4612-1602-5

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