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Mast Cell Biology pp 270–288Cite as

Mast Cells, Angiogenesis and Cancer

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 716))

Abstract

Mast cells (MCs) were first described by Paul Ehrlich 1 in his doctoral thesis. MCs have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. As most tumors contain inflammatory cell infiltrates, which often include plentiful MCs, the question as to the possible contribution of MCs to tumor development has progressively been emerging. In this chapter, the specific involvement of MCs in tumor biology and tumor fate will be considered, with particular emphasis on the capacity of these cells to stimulate tumor growth by promoting angiogenesis and lymphangiogenesis. Data from experimental carcinogenesis and from different tumor settings in human pathology will be summarized. Information to be presented will suggest that MCs may serve as a novel therapeutic target for cancer treatment.

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Authors and Affiliations

  1. Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare Bari, Italy

    Domenico Ribatti

  2. Department of Medical and Morphological Reseach, Section of Anatomy, University of Udine Medical School, Udine, Italy

    Enrico Crivellato

Authors
  1. Domenico Ribatti
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  2. Enrico Crivellato
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Editors and Affiliations

  1. Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    Alasdair M. Gilfillan PhD  & Dean D. Metcalfe MD  & 

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Ribatti, D., Crivellato, E. (2011). Mast Cells, Angiogenesis and Cancer. In: Gilfillan, A.M., Metcalfe, D.D. (eds) Mast Cell Biology. Advances in Experimental Medicine and Biology, vol 716. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9533-9_14

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