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Disturbances of Pain Perception in Disorders of the Peripheral Nervous System

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Pathophysiology of Pain Perception

Part of the book series: Plenum Series in Rehabilitation and Health ((SSRH))

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Abstract

Diabetic neuropathy is one of the most common forms of polyneuropathy. The prevalence among diabetics has been reported as 30% (Tesfaye et al., 1996), and it occurs as a complication of type I (insulin dependent diabetes mellitus, IDDM) as well as type II (non-insulin dependent diabetes mellitus, NIDDM). Its incidence increases with age and duration of diabetes. Diabetic neuropathy affects small and large nerve fibers with varying proportions. In some cases small nerve fiber dysfunction is predominant, leading to autonomic symptoms and disturbance of wound healing. There are several different clinical manifestations with subtypes in terms of the pattern of neurological disturbances, which are presented in the following paragraphs. However, mixed forms of these manifestations occur (Sommer, Donaghy & Wiethölter, 1996).

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  1. Department of Neurology, University of Marburg, Marburg, Germany

    Karsten Schepelmann

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  1. University of Bamberg, Bamberg, Germany

    Stefan Lautenbacher

  2. University of Florida College of Dentistry and Gainesville VA Medical Center, Gainesville, Florida, USA

    Roger B. Fillingim

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Schepelmann, K. (2004). Disturbances of Pain Perception in Disorders of the Peripheral Nervous System. In: Lautenbacher, S., Fillingim, R.B. (eds) Pathophysiology of Pain Perception. Plenum Series in Rehabilitation and Health. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9068-6_10

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