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Insights into the Structural Basis of RNA Recognition by Star Domain Proteins

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Post-Transcriptional Regulation by STAR Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 693))

Abstract

STAR proteins regulate diverse cellular processes and control numerous developmental events. They function at the post-transcriptional level by regulating the stability, sub-cellular distribution, alternative splicing, or translational efficiency of specific mRNA targets. Significant effort has been expended to define the determinants of RNA recognition by STAR proteins, in hopes of identifying new mRNA targets that contribute their role in cellular metabolism and development. This work has lead to the extensive biochemical characterization of the nucleotide sequence specificity of a handful of STAR proteins. In contrast, little structural information is available to analyze the molecular basis of sequence specific RNA recognition by this protein family. This chapter reviews the relevant literature on STAR domain protein structure and provides insights into how these proteins discriminate between different RNA sequences.

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Author information

Authors and Affiliations

  1. Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, LRB-906, Worcester, Massachusetts, 01605

    Sean P. Ryder

  2. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Francesca Massi

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  1. Sean P. Ryder
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  2. Francesca Massi
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Correspondence to Sean P. Ryder .

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Editors and Affiliations

  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Talila Volk BSc, MSc, PhD

  2. Department of Molecular Genetics and Microbiology, Institute of Cell and Molecular Biology, University of Texas at Austin, Austin, Texas, USA

    Karen Artzt BA, PhD

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Ryder, S.P., Massi, F. (2010). Insights into the Structural Basis of RNA Recognition by Star Domain Proteins. In: Volk, T., Artzt, K. (eds) Post-Transcriptional Regulation by STAR Proteins. Advances in Experimental Medicine and Biology, vol 693. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7005-3_3

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