Abstract
Drosophila provides a powerful genetic model for studying the in vivo regulation of biological processes, such as cell proliferation, cell differentiation, and cell death. In a large-scale ectopic-expression screen in Drosophila for identifying genes regulating cell death, the fly homolog of tumor necrosis factor (TNF) encoded by eiger (e da-l i ke cell death trig ger) was identified [7]. eiger was also isolated independently through a molecular approach [15]. eiger encodes a protein of 409 amino acids with a C-terminal TNF homology domain and a hydrophobic transmembrane domain. The sequence of the Eiger’s TNF domain shows highest homology with human EDA-A2 (28%) and also shows significant homology with all known mammalian TNF superfamily members.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Babcock DT, Landry C, Galko MJ (2009) Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae. Curr Biol 19:799–806
Berkey CD, Blow N, Watnick PI (2009) Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. Cell Microbiol 11:461–474
Bidla G, Dushay MS, Theopold U (2007) Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. J Cell Sci 120:1209–1215
Brandt SM, Dionne MS, Khush RS, Pham LN, Vigdal TJ, Schneider DS (2004) Secreted bacterial effectors and host-produced Eiger/TNF drive death in a Salmonella-infected fruit fly. PLoS Biol 2:e418
Brumby AM, Richardson HE (2003) Scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 22:5769–5779
Geuking P, Narasimamurthy R, Basler K (2005) A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Genetics 171:1683–1694
Igaki T, Kanda H, Yamamoto-Goto Y, Kanuka H, Kuranaga E, Aigaki T, Miura M (2002). Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J 21:3009–3018
Igaki T, Pastor-Pareja JC, Aonuma H, Miura M, Xu T (2009). Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell 16:458–465
Johansson KC, Metzendorf C, Soderhall K (2005) Microarray analysis of immune challenged Drosophila hemocytes. Exp Cell Res 305:145–155
Kanda H, Igaki T, Kanuka H, Yagi T, Miura M (2002) Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J Biol Chem 277:28372–28375
Kato K, Awasaki T, Ito K (2009) Neuronal programmed cell death induces glial cell division in the adult Drosophila brain. Development 136:51–59
Lemaitre B, Hoffmann J (2007) The host defense of Drosophila melanogaster. Annu Rev Immunol 25:697–743
Lowe SW, Cepero E, Evan G (2004) Intrinsic tumour suppression. Nature 432:307–315
Miaczynska M, Pelkmans L, Zerial M (2004) Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol 16:400–406
Moreno E, Yan M, Basler K (2002) Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol 12:1263–1268
Schneider DS, Ayres JS, Brandt SM, Costa A, Dionne MS, Gordon MD, Mabery EM, Moule MG, Pham LN, Shirasu-Hiza MM (2007) Drosophila eiger mutants are sensitive to extracellular pathogens. PLoS Pathog 3:e41
Schneider-Brachert W, Tchikov V, Neumeyer J, Jakob M, Winoto-Morbach S, Held-Feindt J, Heinrich M, Merkel O, Ehrenschwender M, Adam D et al (2004) Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21:415–428
Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu T (2007) Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev Cell 13:446–454
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this paper
Cite this paper
Igaki, T., Kanda, H., Okano, H., Xu, T., Miura, M. (2011). Eiger and Wengen: The Drosophila Orthologs of TNF/TNFR. In: Wallach, D., Kovalenko, A., Feldmann, M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6612-4_5
Download citation
DOI: https://doi.org/10.1007/978-1-4419-6612-4_5
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-6611-7
Online ISBN: 978-1-4419-6612-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)