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Heterogeneity of Liver Cancer Stem Cells

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Molecular Genetics of Liver Neoplasia

Part of the book series: Cancer Genetics ((CANGENETICS))

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Abstract

Hepatocellular carcinoma (HCC) is an aggressive disease with a dismal outcome. Although considered to be monoclonal in origin, HCC has heterogeneous pathologies and genetic/genomic profiles, suggesting that HCC may initiate in different cell lineages. Recent advances in cancer and stem-cell biology have revealed similarities between organogenesis and tumorigenesis, including hierarchical organization dictated by a subset of cells with stem-like features termed cancer stem cells (CSCs). Several hepatic stem/progenitor markers have been shown to be useful for the isolation of putative CSCs from HCC, although the expression patterns and phenotypic diversity of CSCs purified by these markers are still elusive. Here, we summarize the current knowledge of liver CSCs and discuss their heterogeneity and commonality.

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Authors and Affiliations

  1. Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Building B, Room b32, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan

    Taro Yamashita

  2. Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, 920-8641, Japan

    Masao Honda M.D., Ph.D. & Shuichi Kaneko M.D.

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  1. Taro Yamashita
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  2. Masao Honda M.D., Ph.D.
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  3. Shuichi Kaneko M.D.
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Correspondence to Taro Yamashita .

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Editors and Affiliations

  1. Lab. Human Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Xin Wei Wang

  2. Lab. Experimental Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Joe W. Grisham

  3. Lab. Experimental Carcinogenesis, National Institute of Health, Convent Drive 37, Bethesda, 20892, Maryland, USA

    Snorri S. Thorgeirsson

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Yamashita, T., Honda, M., Kaneko, S. (2010). Heterogeneity of Liver Cancer Stem Cells. In: Wang, X., Grisham, J., Thorgeirsson, S. (eds) Molecular Genetics of Liver Neoplasia. Cancer Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6082-5_16

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