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Crossroads between Innate and Adaptive Immunity III pp 85–100Cite as

Blimp1: Driving Terminal Differentiation to a T

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 780))

Abstract

B lymphocyte maturation-induced protein-1 (Blimp1) is a transcrip-tional repressor expressed in diverse cell types. In the adaptive immune system, Blimp1 is expressed in lymphocytes that have undergone effector differentiation. Blimp1 is a master regulator of plasma cell differentiation and plays important roles in controlling T cell homeostasis and effector differentiation. Blimp1 can be induced by a variety of cytokines including IL-2, IL-4, IL-12, and IL-21 in addition to TCR and co-stimulatory signals. Blimp1-deficient mice develop spontaneous inflammatory disease mediated by infiltration of activated T cells into tissues. During immune responses Blimp1 is required for the differentiation of plasma cells as well as short-lived CD8+ cytotoxic T cells. Mounting evidence suggests that Blimp1 plays a common role in the terminal differentiation of multiple cell subsets.

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Acknowledgements

This work was supported by grants and fellowships from the National Health and Medical Research Council of Australia (GTB, SLN, AK), the Sylvia and Charles Viertel Foundation and the Howard Hughes Medical Institute (GTB), the Pfizer Australia Research Fellowship (SLN), the Leukemia & Lymphoma Society and the Australian Research Council (AK).

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  1. The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3050, Australia

    Axel Kallies

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  1. Annie Xin
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  2. Stephen L. Nutt
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  3. Gabrielle T. Belz
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  4. Axel Kallies
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Correspondence to Axel Kallies .

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  1. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

  2. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  3. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

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Xin, A., Nutt, S.L., Belz, G.T., Kallies, A. (2011). Blimp1: Driving Terminal Differentiation to a T. In: Pulendran, B., Katsikis, P., Schoenberger, S. (eds) Crossroads between Innate and Adaptive Immunity III. Advances in Experimental Medicine and Biology, vol 780. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5632-3_8

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