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APC Proteins pp 85–106Cite as

APC and Its Modifiers in Colon Cancer

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 656))

Abstract

Colon cancer closely follows the paradigm of a single “gatekeeper gene.” Mutations inactivating the APC (adenomatous polyposis coli) gene are found in ∼80% of all human colon tumors and heterozygosity for such mutations produces an autosomal dominant colon cancer predisposition in humans and in murine models. However, this tight association between a single genotype and phenotype belies a complex association of genetic and epigenetic factors that together generate the broad phenotypic spectrum of both familial and sporadic colon cancers. In this Chapter, we give a general overview of the structure, function and outstanding issues concerning the role of Apc in human and experimental colon cancer. The availability of increasingly close models for human colon cancer in genetically tractable animal species enables the discovery and eventual molecular identification of genetic modifiers of the Apc-mutant phenotypes, connecting the central role of Apc in colon carcinogenesis to the myriad factors that ultimately determine the course of the disease.

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Authors and Affiliations

  1. McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, Wisconsin, 53706, USA

    Lawrence N. Kwong & William F. Dove

  2. Dana-Farber Cancer Institute, Boston, Massachusetts, USA

    Lawrence N. Kwong

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  1. Lawrence N. Kwong
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  2. William F. Dove
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Correspondence to William F. Dove .

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  1. Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK

    Inke S. Näthke

  2. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

    Brooke M. McCartney

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Kwong, L.N., Dove, W.F. (2009). APC and Its Modifiers in Colon Cancer. In: Näthke, I.S., McCartney, B.M. (eds) APC Proteins. Advances in Experimental Medicine and Biology, vol 656. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1145-2_8

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