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Cell Biology and Physiology of the Aging Central Auditory Pathway

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The Aging Auditory System

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 34))

Abstract

The most common manifestation of age-induced hearing loss, presbycusis, is the loss of sensitivity for high-frequency sounds, resulting in difficulties in speech perception, hearing in noisy backgrounds, and distorted loudness perception. These abnormalities typically involve progressive damage to the inner ear and spiral ganglion neurons, leading to a diminished input into the central auditory nervous system. The central components of the auditory system can also undergo direct morphological and physiological changes induced by the biological effects of aging. A combination of direct and secondary changes is most likely to contribute to the manifestations of the aging auditory system. This chapter describes the cell biological and physiological changes that occur during aging in experimental subjects.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Karolinska Institute, 171 77, Stockholm, Sweden

    Barbara Canlon

  2. Neurobiological Research Laboratory, Universitäts-HNO-Klinik, D-79106, Freiburg, Germany

    Robert Benjamin Illing

  3. University of Rochester Medical Center, 14642, Rochester, NY, USA

    Joseph Walton (Associate Professor of Otolaryngology and Neurobiology and Anatomy)

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  1. Barbara Canlon
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  2. Robert Benjamin Illing
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  3. Joseph Walton
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Correspondence to Barbara Canlon .

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Editors and Affiliations

  1. Dept. Hearing & Speech Sciences, University of Maryland, Lefrak Hall 0100 , College Park, 20742, U.S.A.

    Sandra Gordon-Salant

  2. Medical Center, University of Rochester, Elmwood Avenue 601, Rochester, 14642, U.S.A.

    Robert D. Frisina

  3. Dept. Biology, University of Maryland, College Park, 20742-4415, U.S.A.

    Arthur N. Popper

  4. Parmly Hearing Inst., Loyola University Chicago, N. Sheridan Rd. 6525, Chicago, 60626, U.S.A.

    Richard R. Fay

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Canlon, B., Illing, R.B., Walton, J. (2010). Cell Biology and Physiology of the Aging Central Auditory Pathway. In: Gordon-Salant, S., Frisina, R., Popper, A., Fay, R. (eds) The Aging Auditory System. Springer Handbook of Auditory Research, vol 34. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0993-0_3

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