Skip to main content

Distant Metastasis in Elderly Patients with Breast Cancer: Prognosis with Nodal Status

  • Chapter
Methods of Cancer Diagnosis, Therapy and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 1))

  • 2074 Accesses

As our population ages, the number of elderly individuals diagnosed with breast cancer will continue to increase. Currently, the median age at diagnosis for breast cancer patients is 61 years (American Cancer Society, 2006), and women aged 75–79 years have the highest incidence rate of this disease. Despite the considerable number of elderly breast cancer patients being diagnosed today, these patients have traditionally been excluded from clinical trials (Goodwin et al., 1988; Trimble et al., 1994), and therefore controversy remains regarding what constitutes optimal therapy for this population. Certainly, the elderly form a distinct subgroup of patients, in whom tumor biology, comorbidities, and competing risks must be considered in weighing treatment decisions. However, with advances in medical management, our population continues to enjoy everincreasing longevity, and therefore many elderly patients with breast cancer may still be expected to have a reasonable quantity and quality of life. Therefore, it behooves clinicians to consider a variety of factors influencing survival and progression to distant metastasis, and manage patients accordingly.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 309.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 399.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • American Cancer Society. 2006. Breast Cancer Facts & Figures 2005–2006. American Cancer Society, Atlanta

    Google Scholar 

  • Chagpar, A.B., McMasters, K.M., Martin, R.C., Thoene, C., Nurko, J.Y., and Edwards, M.J. 2006. Determinants of early distant metastatic disease in elderly patients with breast cancer.Am. J. Surg.192: 317–321

    Article  PubMed  Google Scholar 

  • Crowe, J.P., Jr., Gordon, N.H., Shenk, R.R., Zollinger, R.M., Jr., Brumberg, D.J., and Shuck, J.M. 1994. Age does not predict breast cancer outcome. Arch. Surg.129: 483–487

    PubMed  Google Scholar 

  • Cummings, F.J., Gray, R., Tormey, D.C., Davis, T.E., Volk, H., Harris, J., Falkson, G., and Bennett, J.M. 1993. Adjuvant tamoxifen versus placebo in elderly women with node-positive breast cancer: long-term follow-up and causes of death.J. Clin. Oncol.11: 29–35

    PubMed  CAS  Google Scholar 

  • Davis, S.J., Karrer, F.W., Moor, B.J., Rose, S.G., and Eakins, G. 1985. Characteristics of breast cancer in women over 80 years of age. Am. J. Surg.150: 655–658

    Article  PubMed  CAS  Google Scholar 

  • Djordjevic, N., Karanikolic, A., and Pesic, M. 2004. Breast cancer in elderly women.Arch. Gerontol. Geriatr. 39: 291–299

    Article  PubMed  Google Scholar 

  • Edge, S.B., Gold, K., Berg, C.D., Meropol, N.J., Tsangaris, T.N., Gray, L., Petersen, B.M., Jr., Hwang, Y.T., and Mandelblatt, J.S. 2002. Patient and provider characteristics that affect the use of axillary dissection in older women with stage I-II breast carcinoma. Cancer 94: 2534–2541

    Article  PubMed  Google Scholar 

  • Feigelson, B.J., Acosta, J.A., Feigelson, H.S., Findley, A., and Saunders, E.L. 1996. T1 breast carcinoma in women 70 years of age and older may not require axillary lymph node dissection.Am. J. Surg.172: 487–489

    Article  PubMed  CAS  Google Scholar 

  • Fisher, B., Jeong, J.H., Anderson, S., Bryant, J., Fisher, E.R., and Wolmark, N. 2002. Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation.N. Engl. J. Med.347: 567–575

    Article  PubMed  Google Scholar 

  • Gennari, R., Curigliano, G., Rotmensz, N., Robertson, C., Colleoni, M., Zurrida, S., Nole, F., de Braud, F., Orlando, L., Leonardi, M.C., Galimberti, V., Intra, M., Veronesi, P., Renne, G., Cinieri, S., Audisio, R.A., Luini, A., Orecchia, R., Viale, G., and Goldhirsch, A. 2004. Breast carcinoma in elderly women: features of disease presentation, choice of local and systemic treatments compared with younger postmenopasual patients.Cancer 101: 1302–1310

    Article  PubMed  Google Scholar 

  • Giordano, S.H., Hortobagyi, G.N., Kau, S.W., Theriault, R.L., and Bondy, M.L. 2005. Breast cancer treatment guidelines in older women.J. Clin. Oncol.23: 783–791

    Article  PubMed  Google Scholar 

  • Goodwin, J.S., Hunt, W.C., Humble, C.G., Key, C.R., and Samet, J.M. 1988. Cancer treatment protocols. Who gets chosen?Arch. Intern. Med.148: 2258–2260

    Article  Google Scholar 

  • Greenfield, S., Blanco, D.M., Elashoff, R.M., and Ganz, P.A. 1987. Patterns of care related to age of breast cancer patients.J. Am. Med. Assoc.257: 2766–2770

    Article  CAS  Google Scholar 

  • Herbsman, H., Feldman, J., Seldera, J., Gardner, B., and Alfonso, A.E. 1981. Survival following breast cancer surgery in the elderly.Cancer 47: 2358–2363

    Article  PubMed  CAS  Google Scholar 

  • Hunt, K.E., Fry, D.E., and Bland, K.I. 1980. Breast carcinoma in the elderly patient: an assessment of operative risk, morbidity and mortality.Am. J. Surg.140: 339–342

    Article  PubMed  CAS  Google Scholar 

  • Law, T.M., Hesketh, P.J., Porter, K.A., Lawn-Tsao, L., McAnaw, R., and Lopez, M.J. 1996. Breast cancer in elderly women: presentation, survival, and treatment options.Surg. Clin. North Am.76: 289–308

    Article  PubMed  CAS  Google Scholar 

  • Litvak, D.A., and Arora, R. 2006. Treatment of elderly breast cancer patients in a community hospital setting.Arch. Surg.141: 985–990

    Article  PubMed  Google Scholar 

  • Mandelblatt, J.S., Edge, S.B., Meropol, N.J., Senie, R., Tsangaris, T., Grey, L., Peterson, B., Hwang, Y.T., and Weeks, J.C. 2002. Sequelae of axillary lymph node dissection in older women with stage 1 and 2 breast carcinoma.Cancer 95: 2445–2454

    Article  PubMed  Google Scholar 

  • Martelli, G., Miceli, R., De Palo, G., Coradini, D., Salvadori, B., Zucali, R., Galante, E., and Marubini, E. 2003. Is axillary lymph node dissection necessary in elderly patients with breast carcinoma who have a clinically uninvolved axilla?Cancer 97: 1156–1163

    Article  PubMed  Google Scholar 

  • Martelli, G., Boracchi, P., De Palo, M., Pilotti, S., Oriana, S., Zucali, R., Daidone, M.G., and De Palo, G. 2005. A randomized trial comparing axillary dissection to no axillary dissection in older patients with T1N0 breast cancer: results after 5 years of follow-up. Ann. Surg.242: 1–6

    Article  PubMed  Google Scholar 

  • McMahon, L.E., Gray, R.J., and Pockaj, B.A. 2005. Is breast cancer sentinel lymph node mapping valuable for patients in their seventies and beyond?Am. J. Surg.190: 366–370

    Article  PubMed  Google Scholar 

  • Morishita, Y. , Tsuda, H., Fukutomi, T., Mukai, K., Shimosato, Y. , and Hirohashi, S. 1997. Clinicopathological characteristics of primary breast cancer in older geriatric women: a study of 39 Japanese patients over 80 years old.Jpn. J. Cancer Res.88: 693–699

    PubMed  CAS  Google Scholar 

  • Mueller, C.B., Ames, F., and Anderson, G.D. 1978. Breast cancer in 3,558 women: age as a significant determinant in the rate of dying and causes of death.Surgery 83: 123–132

    PubMed  CAS  Google Scholar 

  • Nagadowska, M., and Kulakowski, A. 1991. Breast cancer in elderly women: characteristics of the disease.Eur. J. Surg. Oncol.17: 609–614

    PubMed  CAS  Google Scholar 

  • Newlin, M.E., Reiling, R., and Nichols, K. 2002. Necessity of axillary dissection in elderly women with early breast cancer.World J. Surg.26: 1239–1242

    Article  PubMed  Google Scholar 

  • Swanson, R.S., Sawicka, J., and Wood, W.C. 1991. Treatment of carcinoma of the breast in the older geriatric patient.Surg. Gynecol. Obstet.173: 465–469

    PubMed  CAS  Google Scholar 

  • Taghian, A., Jeong, J.H., Mamounas, E., Anderson, S., Bryant, J., Deutsch, M., and Wolmark, N. 2004. Patterns of locoregional failure in patients with operable breast cancer treated by mastectomy and adjuvant chemotherapy with or without tamoxifen and without radiotherapy: results from five National Surgical Adjuvant Breast and Bowel Project randomized clinical trials.J. Clin. Oncol.22: 4247–4254

    Article  PubMed  Google Scholar 

  • Trimble, E.L., Carter, C.L., Cain, D., Freidlin, B., Ungerleider, R.S., and Friedman, M.A. 1994. Representation of older patients in cancer treatment trials.Cancer 74: 2208–2214

    Article  PubMed  CAS  Google Scholar 

  • van Berlo, C.L., Hess, D.A., Nijhuis, P.A., Leys, E., Gerritsen, H.A., and Schapers, R.F. 2003. Ambulatory sentinel node biopsy under local anaesthesia for patients with early breast cancer.Eur. J. Surg. Oncol.29: 383–385

    Article  PubMed  Google Scholar 

  • Veronesi, U., Cascinelli, N., Mariani, L., Greco, M., Saccozzi, R., Luini, A., Aguilar, M., and Marubini, E. 2002. Twenty-year follow-up of a randomized study comparing breast- conserving surgery with radical mastectomy for early breast cancer.N. Engl. J. Med.347: 1227–1232

    Article  PubMed  Google Scholar 

  • U., Paganelli, G., Viale, G., Luini, A., Zurrida, S., Galimberti, V. , Intra, M., Veronesi, P., Robertson, C., Maisonneuve, P., Renne, G., De Cicco, C., De Lucia, F., and Gennari, R. 2003. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer.N. Engl. J. Med.349: 546–553

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science + Business Media B.V.

About this chapter

Cite this chapter

Chagpar, A.B. (2008). Distant Metastasis in Elderly Patients with Breast Cancer: Prognosis with Nodal Status. In: Hayat, M.A. (eds) Methods of Cancer Diagnosis, Therapy and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8369-3_42

Download citation

  • DOI: https://doi.org/10.1007/978-1-4020-8369-3_42

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-8368-6

  • Online ISBN: 978-1-4020-8369-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics