Abstract
Coronary artery dissection (CAD) is the intimal tearing of the coronary arterial wall and can be iatrogenic, spontaneous, or traumatic in origin. CAD is a rare but challenging condition that can cause significant hemodynamic compromise. Management strategies for CAD, such as the use of mechanical circulatory support devices, are available in the clinical setting. However, the incidence, etiology, and optimal management of CAD are not well-defined, emphasizing the need for adequate animal models in preclinical studies. Large animal models provide the human-like conditions necessary for testing and development of potential treatment strategies. In this chapter, we describe a method for the creation of a CAD swine model.
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Acknowledgments
This work was supported by NIH R01 HL139963 (K.I). S.M. was supported by National Institutes of Health T32HL007824-23. We would like to acknowledge the equipment funding from NIH on the animal cathlab C-arm (S10OD034330).
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Leonard, K., Mavropoulos, S.A., Mazurek, R., Ishikawa, K. (2024). Swine Model of Coronary Artery Dissection. In: Ishikawa, K. (eds) Experimental Models of Cardiovascular Diseases. Methods in Molecular Biology, vol 2803. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3846-0_16
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DOI: https://doi.org/10.1007/978-1-0716-3846-0_16
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