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Post-analytical Issues in Hemostasis and Thrombosis Testing: An Update

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Hemostasis and Thrombosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2663))

Abstract

There are typically three phases identified as contributing to the total testing process. The preanalytical phase starts with the clinician and the patient, when laboratory testing is being considered. This phase also includes decisions about which tests to order (or not), patient identification, blood collection, blood transport, sample processing, and storage to name a few. There are many potential failures that may occur in this preanalytical phase, and these are the topic of another chapter in this book. The second phase, the analytical phase, represents the performance of the test, which is essentially covered in various protocols in this book and the previous edition. The third is the post-analytical phase, which is what occurs after sample testing, and is the topic of the current chapter. Post-analytical issues are generally related to reporting and interpretation of test results. This chapter provides a brief description of these events, as well as guidance for preventing or minimizing post-analytical issues. In particular, there are several strategies for improved post-analytical reporting of hemostasis assays, with this providing the final opportunity to prevent serious clinical errors in patient diagnosis or management.

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Abbreviations

aCL:

Anticardiolipin antibody (assay)

APCR:

Activated protein C resistance

aPL:

Antiphospholipid antibody

APS:

Antiphospholipid (antibody) syndrome

APTT:

Activated partial thromboplastin time

AT:

Antithrombin

dRVVT:

Dilute Russell viper venom time

FVL:

Factor V Leiden

KCT:

Kaolin clotting time

LA:

Lupus anticoagulant

PC:

Protein C

PS:

Protein S

VKA:

Vitamin K antagonist

VWD:

Von Willebrand disease

VWF:

Von Willebrand factor

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Conflicts of Interest

RCG receives consulting fees from Sysmex America Inc. All other authors declare no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead, NSW, Australia

    Leonardo Pasalic

  2. School of Medical Sciences, Faculty of Medicine and Health University of Sydney, Westmead Hospital, Westmead, NSW, Australia

    Emmanuel J. Favaloro

  3. School of Dentistry and Medical Sciences, Faculty of Science and Health, Charles Sturt University, Wagga, Wagga, NSW, Australia

    Emmanuel J. Favaloro

  4. Hemostasis & Thrombosis Center, University of California, Davis Health System, Sacramento, CA, USA

    Robert C. Gosselin

  5. Westmead Clinical School, University of Sydney, Westmead, NSW, Australia

    Leonardo Pasalic

  6. Section of Clinical Biochemistry, University of Verona, Verona, Italy

    Giuseppe Lippi

Authors
  1. Emmanuel J. Favaloro
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  2. Robert C. Gosselin
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  3. Leonardo Pasalic
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  4. Giuseppe Lippi
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Corresponding author

Correspondence to Emmanuel J. Favaloro .

Editor information

Editors and Affiliations

  1. School of Medical Sciences, Faculty of Medicine and Health University of Sydney, Westmead Hospital, Westmead, NSW, Australia

    Emmanuel J. Favaloro

  2. Hemostasis & Thrombosis Center, University of California, Davis, Sacramento, CA, USA

    Robert C. Gosselin

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Favaloro, E.J., Gosselin, R.C., Pasalic, L., Lippi, G. (2023). Post-analytical Issues in Hemostasis and Thrombosis Testing: An Update. In: Favaloro, E.J., Gosselin, R.C. (eds) Hemostasis and Thrombosis. Methods in Molecular Biology, vol 2663. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3175-1_53

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  • DOI: https://doi.org/10.1007/978-1-0716-3175-1_53

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