Abstract
Optimal conditions of palladium-catalyzed on-DNA Heck reactions were developed between DNA-conjugated acryl amide/styrene/aryl iodide and broad substrate scopes (aromatic borates/halides/styrene), which can introduce the diversity of building blocks to DNA-encoded libraries.
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References
Beletskaya IP, Cheprakov AV (2000) The Heck reaction as a sharpening stone of Palladium catalysis. Chem Rev 100(8):3009–3066. https://doi.org/10.1021/cr9903048
Gartner ZJ, Kanan MW, Liu DR (2002) Expanding the reaction scope of DNA–templated synthesis. Angew Chemie Int Ed 41(10):1796–1800. https://doi.org/10.1002/1521-3773(20020517)41:10<1796::aid-anie1796>3.0.co;2-z
Wang X, Sun H, Liu J, Zhong W, Zhang M, Zhou H, Dai D, Lu X (2019) Palladium-promoted DNA-compatible Heck reaction. Organ Lett 21:719–723. https://doi.org/10.1021/acs.orglett.8b03926
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Wang, X., Lu, X. (2022). Palladium-Promoted On-DNA Heck Reactions. In: Israel, D., Ding, Y. (eds) DNA-Encoded Chemical Libraries. Methods in Molecular Biology, vol 2541. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2545-3_9
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DOI: https://doi.org/10.1007/978-1-0716-2545-3_9
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