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Mitochondria pp 173–184Cite as

Mitochondrial Toxicity of Organic Arsenicals

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 2497))

Abstract

Arsenic is either notorious toxicant or miracle cure for acute promyelocytic leukemia and several other diseases. It interacts with mitochondria directly or indirectly, by interacting with mitochondrial enzymes, such as respiratory chain complexes and tricarboxylic acid cycle proteins, or affecting mitochondrial homeostasis via ROS or mitochondrial outer membrane permeabilization. Given the ubiquitous presence of mitochondria and indispensable role in cellular metabolism, arsenical-mitochondrial interactions may manifest clinical importance by revealing mechanism of disease curation, preventing severe side effects, and foreseeing potential health issues. Here, we described the interaction between isolated mitochondria and arsenicals.

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Acknowledgments

We gratefully acknowledge the financial support of National Natural Science Foundation of China (22073070, 21673166).

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Authors and Affiliations

  1. State Key Laboratory of Membrane Separation and Membrane Process, School of Chemistry, Tiangong University, Tianjin, P. R. China

    Yu-Jiao Liu & Yi Liu

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  1. Yu-Jiao Liu
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  2. Yi Liu
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Correspondence to Yi Liu .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA

    Namrata Tomar

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Liu, YJ., Liu, Y. (2022). Mitochondrial Toxicity of Organic Arsenicals. In: Tomar, N. (eds) Mitochondria. Methods in Molecular Biology, vol 2497. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2309-1_11

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  • DOI: https://doi.org/10.1007/978-1-0716-2309-1_11

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