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Searching Epitope-Based Vaccines Using Bioinformatics Studies

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Vaccine Design

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2412))

Abstract

Epitope-based vaccines is one of the most recent methodologies applied in bioinformatics studies. This strategy consists of identifying regions of the protein (peptides or epitopes) which show antigen properties capable of stimulating the immune system against proteins from virus, bacteria, fungi, etc. This chapter describes a general procedure to identify epitopes to be used as epitope vaccine using bioinformatics methods including primary protein sequence analyses, epitope predictor, docking, and molecular dynamics simulations for the selection of T- and B-cell epitopes.

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Acknowledgments

We gratefully acknowledge to CONACYT (Grant 312807), SIP/COFAA-IPN.

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Authors and Affiliations

  1. Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotécnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation), Escuela Superior de Medicina, Instituto Politécnico Nacional, México City, Mexico

    Marlet Martínez-Archundia, G. Lizbeth Ramírez-Salinas & José Correa-Basurto

  2. Laboratorio de medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México City, Mexico

    Jazmin García-Machorro

Authors
  1. Marlet Martínez-Archundia
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  2. G. Lizbeth Ramírez-Salinas
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  3. Jazmin García-Machorro
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  4. José Correa-Basurto
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Editor information

Editors and Affiliations

  1. Lankenau Institute for Medical Research, Wynnewood, PA, USA

    Sunil Thomas

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© 2022 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Martínez-Archundia, M., Ramírez-Salinas, G.L., García-Machorro, J., Correa-Basurto, J. (2022). Searching Epitope-Based Vaccines Using Bioinformatics Studies. In: Thomas, S. (eds) Vaccine Design. Methods in Molecular Biology, vol 2412. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1892-9_26

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  • DOI: https://doi.org/10.1007/978-1-0716-1892-9_26

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1891-2

  • Online ISBN: 978-1-0716-1892-9

  • eBook Packages: Springer Protocols

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