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Teleost Fish as an Experimental Model for Vaccine Development

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Vaccine Design

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2411))

Abstract

Advances in vaccine development depend on animal models to test innovative therapies. Recent studies have reported the successful introduction of teleost fish as a new vertebrate model in scientific research, with emphasis on the species Danio rerio (zebrafish). This chapter aims to give an overview of important aspects related to the immune system of fish, as well as the current progress of the successful use of these animals in studies for the development of vaccines, assisting in the determination of efficacy and clinical safety. Among the advantages of using fish for the development of vaccines and immunomodulatory drugs, it is worth highlighting the reproductive capacity of these animals resulting in a high number of individuals belonging to the same spawning, transparent embryos, low cost of breeding and high genetic similarity that favor translational responses to vertebrate organisms like humans.

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Authors and Affiliations

  1. Laboratory of Animal Pharmacology and Toxicology, Brazil University, Descalvado, SP, Brazil

    Marco Antonio de Andrade Belo

  2. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil

    Ives Charlie-Silva

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  1. Marco Antonio de Andrade Belo
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  2. Ives Charlie-Silva
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Editors and Affiliations

  1. Lankenau Institute for Medical Research, Wynnewood, PA, USA

    Sunil Thomas

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de Andrade Belo, M.A., Charlie-Silva, I. (2022). Teleost Fish as an Experimental Model for Vaccine Development. In: Thomas, S. (eds) Vaccine Design. Methods in Molecular Biology, vol 2411. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1888-2_10

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  • DOI: https://doi.org/10.1007/978-1-0716-1888-2_10

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  • Publisher Name: Humana, New York, NY

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