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Viral PDZ Binding Motifs Influence Cell Behavior Through the Interaction with Cellular Proteins Containing PDZ Domains

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PDZ Mediated Interactions

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2256))

Abstract

Viruses have evolved to interact with their hosts. Some viruses such as human papilloma virus, dengue virus, SARS-CoV, or influenza virus encode proteins including a PBM that interact with cellular proteins containing PDZ domains. There are more than 400 cellular protein isoforms with these domains in the human genome, indicating that viral PBMs have a high potential to influence the behavior of the cell. In this review we analyze the most relevant cellular processes known to be affected by viral PBM–cellular PDZ interactions including the establishment of cell–cell interactions and cell polarity, the regulation of cell survival and apoptosis and the activation of the immune system. Special attention has been provided to coronavirus PBM conservation throughout evolution and to the role of the PBMs of human coronaviruses SARS-CoV and MERS-CoV in pathogenesis.

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain

    Carlos Castaño-Rodriguez, Jose M. Honrubia, Javier Gutiérrez-Álvarez, Isabel Sola & Luis Enjuanes

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  1. Carlos Castaño-Rodriguez
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  2. Jose M. Honrubia
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  3. Javier Gutiérrez-Álvarez
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  4. Isabel Sola
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  5. Luis Enjuanes
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Correspondence to Luis Enjuanes .

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  1. Centre de Recherche en CancÕrologie de Marseille, Aix-Marseille University, Inserm, CNRS, Institut Paoli-Calmettes, Marseille, France

    Jean-Paul Borg

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Castaño-Rodriguez, C., Honrubia, J.M., Gutiérrez-Álvarez, J., Sola, I., Enjuanes, L. (2021). Viral PDZ Binding Motifs Influence Cell Behavior Through the Interaction with Cellular Proteins Containing PDZ Domains. In: Borg, JP. (eds) PDZ Mediated Interactions. Methods in Molecular Biology, vol 2256. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1166-1_13

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  • DOI: https://doi.org/10.1007/978-1-0716-1166-1_13

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1165-4

  • Online ISBN: 978-1-0716-1166-1

  • eBook Packages: Springer Protocols

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