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Optical Approaches for Modulating mGlu Receptor Activity

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Metabotropic Glutamate Receptor Technologies

Part of the book series: Neuromethods ((NM,volume 164))

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Abstract

The metabotropic glutamate (mGlu) receptor family plays a diverse role in cellular function. However, differentiation of the specific contributions of individual mGlu subtypes has traditionally relied on pharmacological approaches, which have proven difficult due to many factors including inadequate selectivity for specific receptor subtypes, a lack of discernment in receptor modulation across different cell types, and a lack of spatial and temporal precision over control of receptor activation or inactivation. In this chapter, we review three newly developed approaches that have attempted to circumvent these issues. These approaches include the use of selective photoactivatable mGlu ligands, optogenetic activation of light-sensitive chimeric rhodopsin/mGlu receptors (OptoXRs), and optogenetic modulation of mGlu membrane expression. We hypothesize that these novel methods for targeting mGlu receptors will provide new insight into the roles of individual receptor subtypes in specific cell functions in both normal and disease states.

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Acknowledgments

This work was supported by NIH grants R01 DA043172, R21 DA037741, and R01 AA025590 (MFO) and F32 AA027962 (JMLJ).

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Authors and Affiliations

  1. Department of Psychology, Arizona State University, Tempe, AZ, USA

    Lauren E. Hood, Jonna M. Leyrer-Jackson & M. Foster Olive

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  1. Lauren E. Hood
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  2. Jonna M. Leyrer-Jackson
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  3. M. Foster Olive
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Correspondence to M. Foster Olive .

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Editors and Affiliations

  1. Psychology Department, Arizona State University, Tempe, AZ, USA

    M Foster Olive

  2. Phoenix Children’s Hospital, Barrow Neurological Institute, Phoenix, AZ, USA

    Brian T. Burrows

  3. Psychology Department, Arizona State University, Tempe, AZ, USA

    Jonna M. Leyrer-Jackson

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Hood, L.E., Leyrer-Jackson, J.M., Olive, M.F. (2021). Optical Approaches for Modulating mGlu Receptor Activity. In: Olive, M.F., Burrows, B.T., Leyrer-Jackson, J.M. (eds) Metabotropic Glutamate Receptor Technologies. Neuromethods, vol 164. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1107-4_6

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  • DOI: https://doi.org/10.1007/978-1-0716-1107-4_6

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  • Publisher Name: Humana, New York, NY

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