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Humanized Plasminogen Mouse Model to Study Group A Streptococcus Invasive Disease

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Group A Streptococcus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2136))

Abstract

This chapter presents the methodology to carry out infection of humanized plasminogen mice with Group A Streptococcus (GAS). This model of invasive disease has been widely used within the field to study the virulence of different GAS strains, host–pathogen interactions, the importance of particular virulence factors, and preclinical evaluation of novel treatments and vaccines. The model has shown to be highly reproducible and therefore represents an invaluable tool for GAS research.

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Author information

Authors and Affiliations

  1. Cátedras CONACYT—Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, CDMX, Mexico

    Tania Rivera-Hernandez

  2. Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia

    Mark J. Walker

Authors
  1. Tania Rivera-Hernandez
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  2. Mark J. Walker
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Corresponding author

Correspondence to Tania Rivera-Hernandez .

Editor information

Editors and Affiliations

  1. School of Medical Sciences, The University of Auckland, Auckland, New Zealand

    Thomas Proft

  2. School of Medical Sciences, The University of Auckland, Auckland, New Zealand

    Jacelyn M. S. Loh

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Rivera-Hernandez, T., Walker, M.J. (2020). Humanized Plasminogen Mouse Model to Study Group A Streptococcus Invasive Disease. In: Proft, T., Loh, J. (eds) Group A Streptococcus. Methods in Molecular Biology, vol 2136. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0467-0_24

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  • DOI: https://doi.org/10.1007/978-1-0716-0467-0_24

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0466-3

  • Online ISBN: 978-1-0716-0467-0

  • eBook Packages: Springer Protocols

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