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Group A Streptococcus pp 199–222Cite as

Dynamic Interactions of Group A Streptococcus with Host Macrophages

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 2136))

Abstract

Macrophages play a critical role in Group A Streptococcus (GAS) recognition and the consequent activation of innate immunity and inflammatory responses against the pathogen. In parallel, GAS deploys several strategies for escaping detection and elimination by these efficient phagocytic cells. The events that take place in this GAS–macrophage battleground, the cellular consequences for the pathogen and for the immune cell, and the balance between the magnitude of infection and the efficiency of the host immune response can be investigated with a variety of assays presented in this chapter.

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Author information

Authors and Affiliations

  1. Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA

    Angelica Montenegro Riestra & J. Andrés Valderrama

Authors
  1. Angelica Montenegro Riestra
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  2. J. Andrés Valderrama
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Corresponding author

Correspondence to J. Andrés Valderrama .

Editor information

Editors and Affiliations

  1. School of Medical Sciences, The University of Auckland, Auckland, New Zealand

    Thomas Proft

  2. School of Medical Sciences, The University of Auckland, Auckland, New Zealand

    Jacelyn M. S. Loh

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Riestra, A.M., Valderrama, J.A. (2020). Dynamic Interactions of Group A Streptococcus with Host Macrophages. In: Proft, T., Loh, J. (eds) Group A Streptococcus. Methods in Molecular Biology, vol 2136. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0467-0_15

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  • DOI: https://doi.org/10.1007/978-1-0716-0467-0_15

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0466-3

  • Online ISBN: 978-1-0716-0467-0

  • eBook Packages: Springer Protocols

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