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Synaptic Vesicle Recycling

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Handbook of Neurochemistry and Molecular Neurobiology

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Abstract:

The mechanism of synaptic vesicle recycling has been hotly debated for more than 30 years. The various mechanistic models are presented, and the evidence supporting each model is discussed. It is now well accepted that endocytosis rates span an enormous range and are highly dependent on exocytosis rates. It is also well accepted that clathrin-mediated endocytosis plays a major role in synaptic vesicle recycling. However, it remains to be determined whether endocytic pathways with dramatically different rates operate using the same or different molecular mechanisms.

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Abbreviations

AP:

action potential

AZ:

active zone

CCP:

clathrin-coated pit

CCV:

clathrin-coated vesicle

PM:

plasma membrane

PSP:

postsynaptic potential

SPR:

surface plasmon resonance

SV:

synaptic vesicle

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Acknowledgments

I would like to thank the NIH (NS29051) and the MDA for supporting the work performed in my laboratory. I would like to thank Dr. Jennifer R. Morgan for her contributions to the artwork.

Authors
  1. E. M. Lafer
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Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, New York, 10962, Orangeburg, USA

    Abel Lajtha

  2. Department of Psychiatry Millhauser Labs, Room MHL‐HN–604A, New York University School of Medicine, 550 First Avenue, N.Y. 10016, New York, USA

    Maarten E. A. Reith Ph.D.

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Lafer, E.M. (2007). Synaptic Vesicle Recycling. In: Lajtha, A., Reith, M.E.A. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30380-2_21

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