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Handbook of Epidemiology pp 1875–1925Cite as

Pharmacoepidemiology

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Abstract

In the last decades we have witnessed a tremendous progress in the medical sciences that has led to the development of a great number of new powerful pharmaceuticals. These new medicines enable us to provide much better medical care, but occasionally they will cause harm and give rise to serious adverse reactions that were unexpected from preclinical studies or premarketing clinical trials. Against this background, pharmacoepidemiology has developed as a scientific discipline at the interface between clinical pharmacology and clinical epidemiology (cf. chapter Clinical Epidemiology and Evidence-Based Health Care of this handbook). Pharmacoepidemiology can be defined as the application of epidemiological knowledge, methods, and reasoning to the study of the effects and uses of drugs in human populations (Porta et al. 1997). The application of epidemiological methods – i.e., the use of non-experimental observational techniques – the epidemiological perspective with an emphasis on investigations in large unselected populations and long-term studies, the public health approach, and the philosophy of epidemiology are all extended to the scope of clinical pharmacology, i.e., the study of the effects of pharmaceuticals in humans.

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    1. Edeltraut Garbe
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    2. Samy Suissa
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    1. Department of Epidemiological Methods and Etiologic Research, Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany

      Wolfgang Ahrens

    2. Department of Biometry and Data Management, Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany

      Iris Pigeot

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    Garbe, E., Suissa, S. (2014). Pharmacoepidemiology. In: Ahrens, W., Pigeot, I. (eds) Handbook of Epidemiology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09834-0_31

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