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Phosphoinositide 3-kinase in Health and Disease pp 105–133Cite as

AKT Signaling in Physiology and Disease

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 347))

Abstract

The serine/threonine kinase AKT functions as a critical mediator of signaling downstream of PI3 kinase. Studies over the last two decades have firmly established the importance of AKT in the regulation of cell survival, proliferation, and insulin-dependent metabolic cell responses. AKT executes these diverse tasks through phosphorylation of numerous cellular substrates. Substantial progress has been made in understanding the regulation of AKT activity by upstream kinases and elucidating downstream mechanisms that mediate its myriad cellular effects. Here, we present an overview of AKT regulation and function in physiological and pathological settings. An emphasis is placed on the involvement of aberrant AKT signaling in human diseases ranging from diabetes to cancer and neurological diseases.

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Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA

    Krishna M. Vasudevan & Levi A. Garraway

  2. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA

    Krishna M. Vasudevan & Levi A. Garraway

  3. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Krishna M. Vasudevan & Levi A. Garraway

  4. The Broad Institute, 7 Cambridge Center, Cambridge, MA, 02142, USA

    Levi A. Garraway

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  1. Krishna M. Vasudevan
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Correspondence to Levi A. Garraway .

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  1. Intellikine, North Torreye Pines Road 10931, La Jolla, 92037, California, USA

    Christian Rommel

  2. , Institute of Cancer and the London Schoo, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom

    Bart Vanhaesebroeck

  3. , Dept. Molecular & Exp. Medicine, Scripps Research Institute, N. Torrey Pines Road 10550, La Jolla, 92037, California, USA

    Peter K. Vogt

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Vasudevan, K.M., Garraway, L.A. (2010). AKT Signaling in Physiology and Disease. In: Rommel, C., Vanhaesebroeck, B., Vogt, P. (eds) Phosphoinositide 3-kinase in Health and Disease. Current Topics in Microbiology and Immunology, vol 347. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_66

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