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Large-Scale Population-Based Studies of Blood Metabolome and Brain Health

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Current Topics in Behavioral Neurosciences

Abstract

Metabolomics technologies enable the quantification of multiple metabolomic measures simultaneously, which provides novel insights into molecular aspects of human health and disease. In large-scale, population-based studies, blood is often the preferred biospecimen. Circulating metabolome may relate to brain health either by affecting or reflecting brain metabolism. Peripheral metabolites may act at or cross the blood–brain barrier and, subsequently, influence brain metabolism, or they may reflect brain metabolism if similar pathways are engaged. Peripheral metabolites may also include those penetrating the circulation from the brain, indicating, for example, brain damage. Most brain health-related metabolomics studies have been conducted in the context of neurodegenerative disorders and cognition, but some studies have also focused on neuroimaging markers of these disorders. Moreover, several metabolomics studies of neurodevelopmental disorders have been performed. Here, we provide a brief background on the types of blood metabolites commonly assessed, and we review the literature describing the relationships between human blood metabolome (n > 50 metabolites) and brain health reported in large-scale studies (n > 500 individuals).

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  1. The Hospital for Sick Children, Toronto, ON, Canada

    Zdenka Pausova

  2. Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON, Canada

    Zdenka Pausova

  3. Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland

    Eeva Sliz

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The present work was funded by the National Institutes of Health (R01AG056726) and the Research Council of Finland (338229).

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Pausova, Z., Sliz, E. (2024). Large-Scale Population-Based Studies of Blood Metabolome and Brain Health. In: Current Topics in Behavioral Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2024_463

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