Abstract
Sleep is a phenomenon in animal behavior as enigmatic as it is ubiquitous, and one deeply tied to endocrine function. Though there are still many unanswered questions about the neurochemical basis of sleep and its functions, extensive interactions have been identified between sleep and the endocrine system, in both the endocrine system’s effect on sleep and sleep’s effect on the endocrine system. Unfortunately, until recent years, much research on sleep behavior largely disregarded its connections with the endocrine system. Use of both clinical studies and rodent models to investigate interactions between neuroendocrine function, including biological sex, and sleep therefore presents a promising area of further exploration. Further investigation of the neurobiological and neuroendocrine basis of sleep could have wide impact on a number of clinical and basic science fields. In this review, we summarize the state of basic sleep biology and its connections to the field of neuroendocrine biology, as well as suggest key future directions for the neuroendocrine regulation of sleep that may significantly impact new therapies for sleep disorders in women and men.
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Aalto J, Kiianmaa K (1984) Increased voluntary alcohol drinking concurrent with REM-sleep deprivation. Alcohol 1(1):77–79. PMID: 6543613
Abbott SM, Reid KJ, Zee PC (2015) Circadian rhythm sleep-wake disorders. Psychiatr Clin North Am 38(4):805–823. https://doi.org/10.1016/j.psc.2015.07.012. PMID: 26600110
Acerbi A, McNamara P, Nunn CL (2008) To sleep or not to sleep: the ecology of sleep in artificial organisms. BMC Ecol 8:10. https://doi.org/10.1186/1472-6785-8-10. PMID: 18479523
Ackermann S, Rasch B (2014) Differential effects of non-REM and REM sleep on memory consolidation? Curr Neurol Neurosci Rep 14(2):430. https://doi.org/10.1007/s11910-013-0430-8. PMID: 24395522
Alam MA, Kumar S, McGinty D, Alam MN, Szymusiak R (2014) Neuronal activity in the preoptic hypothalamus during sleep deprivation and recovery sleep. J Neurophysiol 111(2):287–299. https://doi.org/10.1152/jn.00504.2013. PMID: 24174649
Allada R, Cirelli C, Sehgal A (2017) Molecular mechanisms of sleep homeostasis in flies and mammals. Cold Spring Harb Perspect Biol 9(8):a027730. https://doi.org/10.1101/cshperspect.a027730. PMID: 28432135
Aminoff MJ, Boller F, Swaab DF (2011) Handb Clin Neurol 98:vii. https://doi.org/10.1016/B978-0-444-52006-7.00047-2. PMID: 21056174
Arnold AP (2004) Sex chromosomes and brain gender. Nat Rev Neurosci 5(9):701–708. https://doi.org/10.1038/nrn1494. PMID: 15322528
Aryal RP, Kwak PB, Tamayo AG, Gebert M, Chiu PL, Walz T et al (2017) Macromolecular assemblies of the mammalian circadian clock. Mol Cell 67(5):770–782.e6. https://doi.org/10.1016/j.molcel.2017.07.017. PMID: 28886335
Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL (2017) Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev 34:10–22. https://doi.org/10.1016/j.smrv.2016.06.005. PMID: 28648359
Azeez IA, Del Gallo F, Cristino L, Bentivoglio M (2018) Daily fluctuation of orexin neuron activity and wiring: the challenge of “chronoconnectivity”. Front Pharmacol 9:1061
Bailey M, Silver R (2014) Sex differences in circadian timing systems: implications for disease. Front Neuroendocrinol 35(1):111–139. https://doi.org/10.1016/j.yfrne.2013.11.003. PMID: 24287074
Baker FC, Lee KA (2018) Menstrual cycle effects on sleep. Sleep Med Clin 13(3):283–294. https://doi.org/10.1016/j.jsmc.2018.04.002. PMID: 30098748
Baker FC, Mitchell D, Driver HS (2001) Oral contraceptives alter sleep and raise body temperature in young women. Pflugers Arch 442(5):729–737. PMID: 11512029
Bedrosian TA, Herring KL, Walton JC, Fonken LK, Weil ZM, Nelson RJ (2013) Evidence for feedback control of pineal melatonin secretion. Neurosci Lett 542:123–125. https://doi.org/10.1016/j.neulet.2013.03.021. PMID: 23528860
Berger K, Luedemann J, Trenkwalder C, John U, Kessler C (2004) Sex and the risk of restless legs syndrome in the general population. Arch Intern Med 164(2):196–202. https://doi.org/10.1001/archinte.164.2.196. PMID: 14744844
Bixler EO, Papaliaga MN, Vgontzas AN, Lin HM, Pejovic S, Karataraki M et al (2009) Women sleep objectively better than men and the sleep of young women is more resilient to external stressors: effects of age and menopause. J Sleep Res 18(2):221–228. https://doi.org/10.1111/j.1365-2869.2008.00713.x. PMID: 19302341
Blanco-Centurion C, Xu M, Murillo-Rodriguez E, Gerashchenko D, Shiromani AM, Salin-Pascual RJ et al (2006) Adenosine and sleep homeostasis in the basal forebrain. J Neurosci 26(31):8092–8100. https://doi.org/10.1523/JNEUROSCI.2181-06.2006. PMID: 16885223
Born J, Wagner U (2004) Memory consolidation during sleep: role of cortisol feedback. Ann N Y Acad Sci 1032:198–201. https://doi.org/10.1196/annals.1314.020. PMID: 15677410
Bratton DJ, Gaisl T, Wons AM, Kohler M (2015) CPAP vs mandibular advancement devices and blood pressure in patients with obstructive sleep apnea: a systematic review and meta-analysis. JAMA 314(21):2280–2293. https://doi.org/10.1001/jama.2015.16303. PMID: 26624827
Burdick RS, Hoffmann R, Armitage R (2002) Short note: oral contraceptives and sleep in depressed and healthy women. Sleep 25(3):347–349. PMID: 12003166
Cain SW, Dennison CF, Zeitzer JM, Guzik AM, Khalsa SB, Santhi N et al (2010) Sex differences in phase angle of entrainment and melatonin amplitude in humans. J Biol Rhythm 25(4):288–296. https://doi.org/10.1177/0748730410374943. PMID: 20679498
Carrasco-Benso MP, Rivero-Gutierrez B, Lopez-Minguez J, Anzola A, Diez-Noguera A, Madrid JA et al (2016) Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB J 30(9):3117–3123. https://doi.org/10.1096/fj.201600269RR. PMID: 27256623
Cellini N (2017) Memory consolidation in sleep disorders. Sleep Med Rev 35:101–112. https://doi.org/10.1016/j.smrv.2016.09.003. PMID: 27765468
Challet E (2015) Keeping circadian time with hormones. Diabetes Obes Metab 17:176–183. https://doi.org/10.1111/dom.12516. PMID: 26332971
Chang FC, Opp MR (1999) Pituitary CRH receptor blockade reduces waking in the rat. Physiol Behav 67(5):691–696. PMID: 10604839
Cintron D, Lipford M, Larrea-Mantilla L, Spencer-Bonilla G, Lloyd R, Gionfriddo MR et al (2017) Efficacy of menopausal hormone therapy on sleep quality: systematic review and meta-analysis. Endocrine 55(3):702–711. https://doi.org/10.1007/s12020-016-1072-9. PMID: 27515805
Copinschi G, Leproult R, Spiegel K (2014) The important role of sleep in metabolism. Front Horm Res 42:59–72. https://doi.org/10.1159/000358858. PMID: 24732925
Cusmano DM, Hadjimarkou MM, Mong JA (2014) Gonadal steroid modulation of sleep and wakefulness in male and female rats is sexually differentiated and neonatally organized by steroid exposure. Endocrinology 155(1):204–214. https://doi.org/10.1210/en.2013-1624. PMID: 24189140
D’Aurea C, Poyares D, Piovezan RD, Passos G, Tufik S, Mello MT (2015) Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia. Arq Neuropsiquiatr 73(6):516–519. https://doi.org/10.1590/0004-282X20150053. PMID: 26083888
Danielsson K, Markström A, Broman JE, von Knorring L, Jansson-Fröjmark M (2016) Delayed sleep phase disorder in a Swedish cohort of adolescents and young adults: prevalence and associated factors. Chronobiol Int 33(10):1331–1339. https://doi.org/10.1080/07420528.2016.1217002. PMID: 27537980
De Zambotti M, Willoughby AR, Sassoon SA, Colrain IM, Baker FC (2015) Menstrual cycle-related variation in physiological sleep in women in the early menopausal transition. J Clin Endocrinol Metab 100(8):2918–2926. https://doi.org/10.1210/jc.2015-1844. PMID: 26079775
Deurveilher S, Semba K (2003) Indirect projections from the suprachiasmatic nucleus to the median preoptic nucleus in rat. Brain Res 987(1):100–106. PMID: 14499951
Devidze N, Fujimori K, Urade Y, Pfaff DW, Mong JA (2010) Estradiol regulation of lipocalin-type prostaglandin D synthase promoter activity: evidence for direct and indirect mechanisms. Neurosci Lett 474(1):17–21. https://doi.org/10.1016/j.neulet.2010.02.064. PMID: 20193744
Dijk DJ, Cajochen C (1997) Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. J Biol Rhythm 12(6):627–635. https://doi.org/10.1177/074873049701200618. PMID: 9406038
Donahue JE, Stopa EG, Chorsky RL, King JC, Schipper HM, Tobet SA et al (2000) Cells containing immunoreactive estrogen receptor-alpha in the human basal forebrain. Brain Res 856(1–2):142–151. PMID: 10677621
Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen KW et al (2010) A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metab 95(6):2963–2968. https://doi.org/10.1210/jc.2009-2430. PMID: 20371664
Donlea JM (2017) Neuronal and molecular mechanisms of sleep homeostasis. Curr Opin Insect Sci 24:51–57. https://doi.org/10.1016/j.cois.2017.09.008. PMID: 29208223
Dubowy C, Sehgal A (2017) Circadian rhythms and sleep in Drosophila melanogaster. Genetics 205(4):1373–1397. https://doi.org/10.1534/genetics.115.185157. PMID: 28360128
Eastman CI, Tomaka VA, Crowley SJ (2017) Sex and ancestry determine the free-running circadian period. J Sleep Res 26(5):547–550. https://doi.org/10.1111/jsr.12521. PMID: 28332253
Eban-Rothschild A, Giardino WJ, de Lecea L (2017) To sleep or not to sleep: neuronal and ecological insights. Curr Opin Neurobiol 44:132–138. https://doi.org/10.1016/j.conb.2017.04.010. PMID: 28500869
Ehlen JC, Hesse S, Pinckney L, Paul KN (2013) Sex chromosomes regulate nighttime sleep propensity during recovery from sleep loss in mice. PLoS One 8(5):e62205. https://doi.org/10.1371/journal.pone.0062205. PMID: 23658713
Fraser R, Nordin BE (1955) The basal metabolic rate during sleep. Lancet 268(6863):532–533. PMID: 14354919
Frieboes RM, Murck H, Stalla GK, Antonijevic IA, Steiger A (1998) Enhanced slow wave sleep in patients with prolactinoma. J Clin Endocrinol Metab 83(8):2706–2710. https://doi.org/10.1210/jcem.83.8.5016. PMID: 9709935
Fulcher BD, Phillips AJ, Postnova S, Robinson PA (2014) A physiologically based model of orexinergic stabilization of sleep and wake. PLoS One 9(3):e91982. https://doi.org/10.1371/journal.pone.0091982. PMID: 24651580
Fuller PM, Fuller P, Sherman D, Pedersen NP, Saper CB, Lu J (2011) Reassessment of the structural basis of the ascending arousal system. J Comp Neurol 519(5):933–956
Gamaldo CE, Earley CJ (2006) Restless legs syndrome: a clinical update. Chest 130(5):1596–1604. https://doi.org/10.1378/chest.130.5.1596. PMID: 17099042
Gandhi AV, Mosser EA, Oikonomou G, Prober DA (2015) Melatonin is required for the circadian regulation of sleep. Neuron 85(6):1193–1199
Giménez S, Romero S, Gich I, Clos S, Grasa E, Antonijoan RM et al (2011) Sex differences in sleep after a single oral morning dose of olanzapine in healthy volunteers. Hum Psychopharmacol 26(7):498–507. https://doi.org/10.1002/hup.1232. PMID: 21953682
Goel N, Kim H, Lao RP (2005) Gender differences in polysomnographic sleep in young healthy sleepers. Chronobiol Int 22(5):905–915. https://doi.org/10.1080/07420520500263235. PMID: 16298775
Goldstein-Piekarski AN, Greer SM, Saletin JM, Harvey AG, Williams LM, Walker MP (2018) Sex, sleep deprivation, and the anxious brain. J Cogn Neurosci 30(4):565–578. https://doi.org/10.1162/jocn_a_01225. PMID: 29244642
Golombek DA, Rosenstein RE (2010) Physiology of circadian entrainment. Physiol Rev 90(3):1063–1102. https://doi.org/10.1152/physrev.00009.2009. PMID: 20664079
Grafe LA, Bhatnagar S (2018) Orexins and stress. Front Neuroendocrinol 51:132–145
Greenblatt DJ, Harmatz JS, Singh NN, Steinberg F, Roth T, Moline ML et al (2014) Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration. J Clin Pharmacol 54(3):282–290. https://doi.org/10.1002/jcph.220. PMID: 24203450
Greene R, Siegel J (2004) Sleep: a functional enigma. NeuroMolecular Med 5(1):59–68. https://doi.org/10.1385/NMM:5:1:059. PMID: 15001813
Hadjimarkou MM, Benham R, Schwarz JM, Holder MK, Mong JA (2008) Estradiol suppresses rapid eye movement sleep and activation of sleep-active neurons in the ventrolateral preoptic area. Eur J Neurosci 27(7):1780–1792. https://doi.org/10.1111/j.1460-9568.2008.06142.x. PMID: 18371078
Held K, Antonijevic I, Murck H, Künzel H, Steiger A (2005) Alpha-helical CRH exerts CRH agonistic effects on sleep-endocrine activity in humans. Neuropsychobiology 52(2):62–67. https://doi.org/10.1159/000086606. PMID: 15990457
Hickie IB, Rogers NL (2011) Novel melatonin-based therapies: potential advances in the treatment of major depression. Lancet 378(9791):621–631. https://doi.org/10.1016/S0140-6736(11)60095-0. PMID: 21596429
Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S et al (2018) A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice. Proc Natl Acad Sci U S A 115(41):10458–10463. https://doi.org/10.1073/pnas.1810823115. PMID: 30254177
Huang ZL, Zhang Z, Qu WM (2014) Roles of adenosine and its receptors in sleep-wake regulation. Int Rev Neurobiol 119:349–371. https://doi.org/10.1016/B978-0-12-801022-8.00014-3. PMID: 25175972
Hutchison IC, Rathore S (2015) The role of REM sleep theta activity in emotional memory. Front Psychol 6:1439. https://doi.org/10.3389/fpsyg.2015.01439. PMID: 26483709
James FO, Walker CD, Boivin DB (2004) Controlled exposure to light and darkness realigns the salivary cortisol rhythm in night shift workers. Chronobiol Int 21(6):961–972. PMID: 15646242
Johnson EO, Roth T, Schultz L, Breslau N (2006) Epidemiology of DSM-IV insomnia in adolescence: lifetime prevalence, chronicity, and an emergent gender difference. Pediatrics 117(2):e247–e256. https://doi.org/10.1542/peds.2004-2629. PMID: 16452333
Kapás L, Hong L, Cady AB, Opp MR, Postlethwaite AE, Seyer JM et al (1992) Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor-alpha and TNF-alpha fragments. Am J Phys 263(3 Pt 2):R708–R715. https://doi.org/10.1152/ajpregu.1992.263.3.R708. PMID: 1357984
Karatsoreos IN, Butler MP, Lesauter J, Silver R (2011) Androgens modulate structure and function of the suprachiasmatic nucleus brain clock. Endocrinology 152(5):1970–1978. https://doi.org/10.1210/en.2010-1398. PMID: 21363939
Kayaba M, Sasai-sakuma T, Inoue Y (2018) Clinical significance of social jetlag in patients with excessive daytime sleepiness. Chronobiol Int 35(12):1637–1646
Koehl M, Battle S, Meerlo P (2006) Sex differences in sleep: the response to sleep deprivation and restraint stress in mice. Sleep 29(9):1224–1231. PMID: 17040010
Krause AJ, Simon EB, Mander BA, Greer SM, Saletin JM, Goldstein-Piekarski AN et al (2017) The sleep-deprived human brain. Nat Rev Neurosci 18(7):404–418. https://doi.org/10.1038/nrn.2017.55. PMID: 28515433
Kumar S, Rai S, Hsieh KC, McGinty D, Alam MN, Szymusiak R (2013) Adenosine A(2A) receptors regulate the activity of sleep regulatory GABAergic neurons in the preoptic hypothalamus. Am J Physiol Regul Integr Comp Physiol 305(1):R31–R41. https://doi.org/10.1152/ajpregu.00402.2012. PMID: 23637137
Lancel M, Faulhaber J, Holsboer F, Rupprecht R (1996) Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators. Am J Phys 271(4 Pt 1):E763–E772. https://doi.org/10.1152/ajpendo.1996.271.4.E763. PMID: 8897866
Lanquart JP, Nardone P, Hubain P, Loas G, Linkowski P (2018) The dichotomy between low frequency and delta waves in human sleep: a reappraisal. J Neurosci Methods 293:234–246. https://doi.org/10.1016/j.jneumeth.2017.09.019. PMID: 28982607
Lazarus M, Chen JF, Huang ZL, Urade Y, Fredholm BB (2017) Adenosine and sleep. Handb Exp Pharmacol 7:238–245. https://doi.org/10.1007/164_2017_36. PMID: 28646346
Lucey BP, Bateman RJ (2014) Amyloid-β diurnal pattern: possible role of sleep in Alzheimer’s disease pathogenesis. Neurobiol Aging 35(Suppl 2):S29–S34. https://doi.org/10.1016/j.neurobiolaging.2014.03.035. PMID: 24910393
Macedo AC, Balouch S, Tabet N (2017) Is sleep disruption a risk factor for Alzheimer’s disease? J Alzheimers Dis 58(4):993–1002. https://doi.org/10.3233/JAD-161287. PMID: 28550253
Marchant EG, Mistlberger RE (1997) Anticipation and entrainment to feeding time in intact and SCN-ablated C57BL/6j mice. Brain Res 765(2):273–282. PMID: 9313900
Matheson E, Hainer BL (2017) Insomnia: pharmacologic therapy. Am Fam Physician 96(1):29–35
Methippara MM, Kumar S, Alam MN, Szymusiak R, McGinty D (2005) Effects on sleep of microdialysis of adenosine A1 and A2a receptor analogs into the lateral preoptic area of rats. Am J Physiol Regul Integr Comp Physiol 289(6):R1715–R1723. https://doi.org/10.1152/ajpregu.00247.2005. PMID: 16109808
Micic G, Lovato N, Gradisar M, Ferguson SA, Burgess HJ, Lack LC (2016) The etiology of delayed sleep phase disorder. Sleep Med Rev 27:29–38. https://doi.org/10.1016/j.smrv.2015.06.004. PMID: 26434674
Miki K, Yoshimoto M (2013) Sympathetic nerve activity during sleep, exercise, and mental stress. Auton Neurosci 174(1–2):15–20. https://doi.org/10.1016/j.autneu.2012.12.007. PMID: 23332904
Model Z, Butler MP, LeSauter J, Silver R (2015) Suprachiasmatic nucleus as the site of androgen action on circadian rhythms. Horm Behav 73:1–7. https://doi.org/10.1016/j.yhbeh.2015.05.007. PMID: 26012711
Mong JA, Cusmano DM (2016) Sex differences in sleep: impact of biological sex and sex steroids. Philos Trans R Soc Lond Ser B Biol Sci 371(1688):20150110. https://doi.org/10.1098/rstb.2015.0110. PMID: 26833831
Mong JA, Devidze N, Frail DE, O’Connor LT, Samuel M, Choleris E et al (2003) Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: evidence from high-density oligonucleotide arrays and in situ hybridization. Proc Natl Acad Sci U S A 100(1):318–323. https://doi.org/10.1073/pnas.262663799. PMID: 12518068
Morgan D, Tsai SC (2015) Sleep and the endocrine system. Crit Care Clin 31(3):403–418. https://doi.org/10.1016/j.ccc.2015.03.004. PMID: 26118912
Morgan PJ, Barrett P, Howell HE, Helliwell R (1994) Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochem Int 24(2):101–146. PMID: 8161940
Moser D, Anderer P, Gruber G, Parapatics S, Loretz E, Boeck M et al (2009) Sleep classification according to AASM and Rechtschaffen & Kales: effects on sleep scoring parameters. Sleep 32(2):139–149. PMID: 19238800
Mouret J, Coindet J, Debilly G, Chouvet G (1978) Suprachiasmatic nuclei lesions in the rat: alterations in sleep circadian rhythms. Electroencephalogr Clin Neurophysiol 45(3):402–408. PMID: 79478
Nugent BM, Wright CL, Shetty AC, Hodes GE, Lenz KM, Mahurkar A et al (2015) Brain feminization requires active repression of masculinization via DNA methylation. Nat Neurosci 18(5):690–697. https://doi.org/10.1038/nn.3988. PMID: 25821913
Nurminen T (1998) Shift work and reproductive health. Scand J Work Environ Health 24(Suppl 3):28–34. PMID: 9916814
Obal F, Opp M, Cady AB, Johannsen L, Postlethwaite AE, Poppleton HM et al (1990) Interleukin 1 alpha and an interleukin 1 beta fragment are somnogenic. Am J Phys 259(3 Pt 2):R439–R446. https://doi.org/10.1152/ajpregu.1990.259.3.R439. PMID: 2396703
Ocampo-Garcés A, Ibáñez F, Perdomo G, Torrealba F (2011) Orexin-B-saporin lesions in the lateral hypothalamus enhance photic masking of rapid eye movement sleep in the albino rat. J Sleep Res 20(1 Pt 1):3–11. https://doi.org/10.1111/j.1365-2869.2010.00864.x. PMID: 20626614
Ohayon MM (2002) Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev 6(2):97–111. PMID: 12531146
Pase MP, Himali JJ, Grima NA, Beiser AS, Satizabal CL, Aparicio HJ et al (2017) Sleep architecture and the risk of incident dementia in the community. Neurology 89(12):1244–1250. https://doi.org/10.1212/WNL.0000000000004373. PMID: 28835407
Paul KN, Dugovic C, Turek FW, Laposky AD (2006) Diurnal sex differences in the sleep-wake cycle of mice are dependent on gonadal function. Sleep 29(9):1211–1223. PMID: 17040009
Pavlova M (2017) Circadian rhythm sleep-wake disorders. Continuum 23(4):1051–1063. https://doi.org/10.1212/CON.0000000000000499. PMID: 28777176
Perelis M, Ramsey KM, Marcheva B, Bass J (2016) Circadian transcription from beta cell function to diabetes pathophysiology. J Biol Rhythm 31(4):323–336. https://doi.org/10.1177/0748730416656949. PMID: 27440914
Peter-Derex L, Yammine P, Bastuji H, Croisile B (2015) Sleep and Alzheimer’s disease. Sleep Med Rev 19:29–38. https://doi.org/10.1016/j.smrv.2014.03.007. PMID: 24846773
Pietrowsky R, Meyrer R, Kern W, Born J, Fehm HL (1994) Effects of diurnal sleep on secretion of cortisol, luteinizing hormone, and growth hormone in man. J Clin Endocrinol Metab 78(3):683–687. https://doi.org/10.1210/jcem.78.3.8126142. PMID: 8126142
Plog BA, Nedergaard M (2018) The glymphatic system in central nervous system health and disease: past, present, and future. Annu Rev Pathol 13:379–394. https://doi.org/10.1146/annurev-pathol-051217-111018. PMID: 29195051
Punjabi NM (2008) The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5(2):136–143. https://doi.org/10.1513/pats.200709-155MG. PMID: 18250205
Ramírez DA, Vieyra E, González AI, Morán C, Domínguez R, Morales-Ledesma L (2017) Both the suprachiasmatic nucleus and the superior ovarian nerve contribute to the processes of ovulation and steroid hormone secretion on proestrus. Reprod Sci 24(6):844–855. https://doi.org/10.1177/1933719116670307. PMID: 27688242
Rasmussen MH, Wildschiødtz G, Juul A, Hilsted J (2008) Polysomnographic sleep, growth hormone insulin-like growth factor-I axis, leptin, and weight loss. Obesity (Silver Spring) 16(7):1516–1521. https://doi.org/10.1038/oby.2008.249. PMID: 18464752
Raven F, Van der Zee EA, Meerlo P, Havekes R (2018) The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function. Sleep Med Rev 39:3–11. https://doi.org/10.1016/j.smrv.2017.05.002. PMID: 28641933
Redline S, Kirchner HL, Quan SF, Gottlieb DJ, Kapur V, Newman A (2004) The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architecture. Arch Intern Med 164(4):406–418. https://doi.org/10.1001/archinte.164.4.406. PMID: 14980992
Reichert CF, Maire M, Schmidt C, Cajochen C (2016) Sleep-wake regulation and its impact on working memory performance: the role of adenosine. Biology 5(1):E11. https://doi.org/10.3390/biology5010011. PMID: 26861410
Ribeiro AC, Pfaff DW, Devidze N (2009) Estradiol modulates behavioral arousal and induces changes in gene expression profiles in brain regions involved in the control of vigilance. Eur J Neurosci 29(4):795–801. https://doi.org/10.1111/j.1460-9568.2009.06620.x. PMID: 19200066
Rønnekleiv OK, Kelly MJ (2005) Diversity of ovarian steroid signaling in the hypothalamus. Front Neuroendocrinol 26(2):65–84. https://doi.org/10.1016/j.yfrne.2005.05.001. PMID: 16009409
Sack RL, Brandes RW, Kendall AR, Lewy AJ (2000) Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med 343(15):1070–1077
Santiago JR, Nolledo MS, Kinzler W, Santiago TV (2001) Sleep and sleep disorders in pregnancy. Ann Intern Med 134(5):396–408
Saper CB, Fuller PM (2017) Wake-sleep circuitry: an overview. Curr Opin Neurobiol 44:186–192
Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE (2010) Sleep state switching. Neuron 68(6):1023–1042. https://doi.org/10.1016/j.neuron.2010.11.032. PMID: 21172606
Sato T, Matsumoto T, Kawano H, Watanabe T, Uematsu Y, Sekine K et al (2004) Brain masculinization requires androgen receptor function. Proc Natl Acad Sci U S A 101(6):1673–1678. https://doi.org/10.1073/pnas.0305303101. PMID: 14747651
Sawaki Y, Nihonmatsu I, Kawamura H (1984) Transplantation of the neonatal suprachiasmatic nuclei into rats with complete bilateral suprachiasmatic lesions. Neurosci Res 1(1):67–72. PMID: 6536887
Schlaich M, Straznicky N, Lambert E, Lambert G (2015) Metabolic syndrome: a sympathetic disease? Lancet Diabetes Endocrinol 3(2):148–157. https://doi.org/10.1016/S2213-8587(14)70033-6. PMID: 24731670
Schmid SM, Hallschmid M, Schultes B (2015) The metabolic burden of sleep loss. Lancet Diabetes Endocrinol 3(1):52–62. https://doi.org/10.1016/S2213-8587(14)70012-9. PMID: 24731536
Schwab RJ, Kim C, Bagchi S, Keenan BT, Comyn FL, Wang S et al (2015) Understanding the anatomic basis for obstructive sleep apnea syndrome in adolescents. Am J Respir Crit Care Med 191(11):1295–1309. https://doi.org/10.1164/rccm.201501-0169OC. PMID: 25835282
Schwartz MD, Mong JA (2013) Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner. Am J Physiol Regul Integr Comp Physiol 305(3):R271–R280. https://doi.org/10.1152/ajpregu.00474.2012. PMID: 23678032
Schwierin B, Borbély AA, Tobler I (1998) Sleep homeostasis in the female rat during the estrous cycle. Brain Res 811(1–2):96–104. PMID: 9804908
Shinohara K, Honma S, Katsuno Y, Abe H, Honma K (1998) Circadian release of amino acids in the suprachiasmatic nucleus in vitro. Neuroreport 9(1):137–140. PMID: 9592063
Simasko SM, Mukherjee S (2009) Novel analysis of sleep patterns in rats separates periods of vigilance cycling from long-duration wake events. Behav Brain Res 196(2):228–236. https://doi.org/10.1016/j.bbr.2008.09.003. PMID: 18835301
Späth-Schwalbe E, Gofferje M, Kern W, Born J, Fehm HL (1991) Sleep disruption alters nocturnal ACTH and cortisol secretory patterns. Biol Psychiatry 29(6):575–584. PMID: 1647222
Spiegel K, Leproult R, Van Cauter E (1999) Impact of sleep debt on metabolic and endocrine function. Lancet 354(9188):1435–1439. https://doi.org/10.1016/S0140-6736(99)01376-8. PMID: 10543671
Squarcini CF, Pires ML, Lopes C, Benedito-Silva AA, Esteves AM, Cornelissen-Guillaume G et al (2013) Free-running circadian rhythms of muscle strength, reaction time, and body temperature in totally blind people. Eur J Appl Physiol 113(1):157–165. https://doi.org/10.1007/s00421-012-2415-8. PMID: 22618303
Steiger A (2002) Sleep and the hypothalamo-pituitary-adrenocortical system. Sleep Med Rev 6(2):125–138. PMID: 12531148
Stenberg D (2007) Neuroanatomy and neurochemistry of sleep. Cell Mol Life Sci 64(10):1187–1204. https://doi.org/10.1007/s00018-007-6530-3. PMID: 17364141
Steyn FJ, Ngo ST (2017) Endocrine rhythms of growth hormone release: insights from animal studies. Best Pract Res Clin Endocrinol Metab 31(6):521–533. https://doi.org/10.1016/j.beem.2017.10.009. PMID: 29224665
Sun X, Whitefield S, Rusak B, Semba K (2001) Electrophysiological analysis of suprachiasmatic nucleus projections to the ventrolateral preoptic area in the rat. Eur J Neurosci 14(8):1257–1274. PMID: 11703455
Szymusiak R, McGinty D (2008) Hypothalamic regulation of sleep and arousal. Ann N Y Acad Sci 1129:275–286. https://doi.org/10.1196/annals.1417.027. PMID: 18591488
Trotti LM, Becker LA (2019) Iron for the treatment of restless legs syndrome. Cochrane Database Syst Rev 1:CD007834. https://doi.org/10.1002/14651858.CD007834.pub3. PMID: 30609006
van Cauter E, Plat L (1996) Physiology of growth hormone secretion during sleep. J Pediatr 128(5 Pt 2):S32–S37. PMID: 8627466
Van Melick MJ, Van Beukering MD, Mol BW, Frings-Dresen MH, Hulshof CT (2014) Shift work, long working hours and preterm birth: a systematic review and meta-analysis. Int Arch Occup Environ Health 87(8):835–849. https://doi.org/10.1007/s00420-014-0934-9. PMID: 24584887
Vida B, Hrabovszky E, Kalamatianos T, Coen CW, Liposits Z, Kalló I (2008) Oestrogen receptor alpha and beta immunoreactive cells in the suprachiasmatic nucleus of mice: distribution, sex differences and regulation by gonadal hormones. J Neuroendocrinol 20(11):1270–1277. https://doi.org/10.1111/j.1365-2826.2008.01787.x. PMID: 18752649
Villafuerte G, Miguel-Puga A, Rodríguez EM, Machado S, Manjarrez E, Arias-Carrión O (2015) Sleep deprivation and oxidative stress in animal models: a systematic review. Oxid Med Cell Longev 2015:234952. https://doi.org/10.1155/2015/234952. PMID: 25945148
Vyazovskiy VV, Kopp C, Wigger E, Jones ME, Simpson ER, Tobler I (2006) Sleep and rest regulation in young and old oestrogen-deficient female mice. J Neuroendocrinol 18(8):567–576. https://doi.org/10.1111/j.1365-2826.2006.01452.x. PMID: 16867177
Wagner DR (1999) Circadian rhythm sleep disorders. Curr Treat Options Neurol 1(4):299–308. PMID: 11096717
Wang Z, Ma J, Miyoshi C, Li Y, Sato M, Ogawa Y et al (2018) Quantitative phosphoproteomic analysis of the molecular substrates of sleep need. Nature 558(7710):435–439. https://doi.org/10.1038/s41586-018-0218-8. PMID: 29899451
White DP (2017) Advanced concepts in the pathophysiology of obstructive sleep apnea. Adv Otorhinolaryngol 80:7–16. https://doi.org/10.1159/000470522. PMID: 28738382
Wirz-Justice A (2018) Seasonality in affective disorders. Gen Comp Endocrinol 258:244–249. https://doi.org/10.1016/j.ygcen.2017.07.010. PMID: 28711512
Wittert G (2014) The relationship between sleep disorders and testosterone in men. Asian J Androl 16(2):262–265. https://doi.org/10.4103/1008-682X.122586. PMID: 24435056
Wright KP, Drake AL, Frey DJ, Fleshner M, Desouza CA, Gronfier C et al (2015) Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance. Brain Behav Immun 47:24–34. https://doi.org/10.1016/j.bbi.2015.01.004. PMID: 25640603
Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M et al (2013) Sleep drives metabolite clearance from the adult brain. Science 342(6156):373–377. https://doi.org/10.1126/science.1241224. PMID: 24136970
Yanik G, Glaum S, Radulovacki M (1987) The dose-response effects of caffeine on sleep in rats. Brain Res 403(1):177–180. PMID: 3828812
Zeitzer JM, Morales-Villagran A, Maidment NT, Behnke EJ, Ackerson LC, Lopez-Rodriguez F et al (2006) Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study. Sleep 29(4):455–461. PMID: 16676778
Zhang BJ, Huang ZL, Chen JF, Urade Y, Qu WM (2017) Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin 38(4):469–476. https://doi.org/10.1038/aps.2016.140. PMID: 28112177
Zhdanova IV, Wang SY, Leclair OU, Danilova NP (2001) Melatonin promotes sleep-like state in zebrafish. Brain Res 903(1–2):263–268
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Smith, P.C., Mong, J.A. (2019). Neuroendocrine Control of Sleep. In: Coolen, L., Grattan, D. (eds) Neuroendocrine Regulation of Behavior. Current Topics in Behavioral Neurosciences, vol 43. Springer, Cham. https://doi.org/10.1007/7854_2019_107
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