Abstract
Tendon injuries are frequent and are responsible for substantial morbidity both in sports and in the workplace. Despite the endogenous mechanisms of tendon repair and regeneration, tendon healing upon injury is slow and often insufficient to restore complete biomechanics functionality.
Inflammation has a pivotal role in tendon healing and failed healing responses contribute to the progression of tendinopathies. However, the molecular and cellular mechanisms involved are poorly understood requiring further insights.
During inflammation, bioactive molecules such as cytokines secreted locally at the injury site, influence resident stem cells that contribute as modulatory agents over the niche towards homeostasis, holding great promise as therapeutic agents for tendon pathological conditions associated to unresolved inflammation and failed healing.
This review overviews the role of cytokines and resident cells, focusing on the participation of tendon stem cell population in inflammation and tendon healing upon injury and their potential action in resolution of pathological conditions.
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Abbreviations
- CTGF:
-
connective tissue growth factor
- ECM:
-
extracelular matrix
- MMPs:
-
matrix metalloproteinases
- MSCs:
-
mesenchymal stem/stromal cell
- NO:
-
nitric oxide
- STAT3:
-
activator of transcription 3
- TDSCs:
-
tendon-derived stem cells
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Acknowledgements
The authors acknowledge the financial support from Fundação para a Ciência e Tecnologia (FCT) for the doctoral grant PD/BD/128089/2016, the project NORTE-01-0145-FEDER-000021 supported by Norte Portugal Regional Operational Programme (NORTE 2020) and HORIZON 2020 under the TEAMING GRANT agreement No 739572 – The Discoveries CTR.
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Vinhas, A., Rodrigues, M.T., Gomes, M.E. (2018). Exploring Stem Cells and Inflammation in Tendon Repair and Regeneration. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 2. Advances in Experimental Medicine and Biology(), vol 1089. Springer, Cham. https://doi.org/10.1007/5584_2018_258
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DOI: https://doi.org/10.1007/5584_2018_258
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