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Rehabilitation Science in Context pp 73–82Cite as

Bioactive Oleic Derivatives of Dopamine: A Review of the Therapeutic Potential

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Part of the book series: Advances in Experimental Medicine and Biology ((CLEXBI,volume 1096))

Abstract

Lipid derivatives of dopamine are a novel class of compounds raising a research interest due to the potential of their being a vehicle for dopamine delivery to the brain. The aim of the present paper is to review the main features of the two most prominent bioactive members of this family, namely, N-oleoyl-dopamine (OLDA) and 3′-O-methyl-N-oleoyl-dopamine (OMe-OLDA), with emphasis on the possible therapeutic properties.

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Acknowledgments

The dopamides reviewed in this article were synthetized in the Laboratory of Natural Products Chemistry, The Faculty of Chemistry, University of Warsaw. We remain appreciative of Dr. Zbigniew Czarnocki and Piotr Roszkowski’s dexterity in the elaboration of de novo synthesis of the dopamides, and we are thankful for the provision of the compounds for our biological studies. We also thank Dr. Agnieszka Stasińska for giving a hand in some of the experiments described herein.

Conflicts of Interest

The authors of this article are the inventors of the European (EP 2324824) and the US patents (US 8697898) covering the potential medical applications of OLDA and OMe-OLDA. The patent procedures were in part financed by the EU Innovative Economy grant POIG 1.3.2.-14–047/11.

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Authors and Affiliations

  1. Faculty of Physiotherapy, Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

  2. Laboratory of Respiration Physiology, Mossakowski Medical Research Centre PAS, Warsaw, Poland

    Dominika Zajac

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  1. Mieczyslaw Pokorski
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  2. Dominika Zajac
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Correspondence to Mieczyslaw Pokorski .

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  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Pokorski, M., Zajac, D. (2018). Bioactive Oleic Derivatives of Dopamine: A Review of the Therapeutic Potential. In: Pokorski, M. (eds) Rehabilitation Science in Context . Advances in Experimental Medicine and Biology(), vol 1096. Springer, Cham. https://doi.org/10.1007/5584_2018_197

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