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Mechanisms of Lasting Change in Anxiety Induced by Severe Stress

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PTSD

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References

  • Adamec RE (1993) Lasting effects of FG-7142 on anxiety, aggression and limbic physiology in the cat. J Psychopharmacol 7:232–248

    Article  CAS  Google Scholar 

  • Adamec R (1997) Transmitter systems involved in neural plasticity underlying increased anxiety and defense-implications for understanding anxiety following traumatic stress. Neurosci Biobehav Rev 21:755–765

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE (1998a) Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior. Study 1. Role of NMDA receptors in efferent transmission from the cat amygdala. J Psychopharmacol 12:122–128

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE (1998b) Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior. Study 2. The effects on behavior of block of NMDA receptors prior to injection of FG-7142. J Psychopharmacol 12:129–136

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE (1998c) Evidence that NMDA-dependent limbic neural plasticity in the right hemisphere mediates pharmacological stressor (FG-7142)-induced lasting increases in anxiety-like behavior. Study 3. The effects on amygdala efferent physiology of block of NMDA receptors prior to injection of FG-7142 and its relationship to behavioral change. J Psychopharmacol 12:227–238

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE (1999) Evidence that limbic neural plasticity in the right hemisphere mediates partial kindling induced lasting increases in anxiety-like behavior: effects of low frequency stimulation (quenching?) on long term potentiation of amygdala efferents and behavior following kindling. Brain Res 839:133–152

    Article  PubMed  CAS  Google Scholar 

  • Adamec R (2001) Does long term potentiation in periacqueductal gray (PAG) mediate lasting changes in rodent ALB produced by predator stress? Effects of low frequency stimulation (LFS) of PAG on place preference and changes in ALB produced by predator stress. Behav Brain Res 120:111–135

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE (2003) Stress effects on limbic function and behavior. Prog Neuropsychopharmacol Biol Psychiat 27:1173–1175

    Article  Google Scholar 

  • Adamec RE, Shallow T (1993) Lasting effects on rodent anxiety of a single exposure to a cat. Physiol Behav 54:101–109

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE, Shallow T, Budgell J (1997) Blockade of CCK(B) but not CCK(A) receptors before and after the stress of predator exposure prevents lasting increases in anxiety-like behavior: implications for anxiety associated with posttraumatic stress disorder. Behav Neurosci 111:435–449

    Article  PubMed  CAS  Google Scholar 

  • Adamec R, Kent P, Anisman H, Shallow T, Merali Z (1998) Neural plasticity, neuropeptides, and anxiety in animals — implications for understanding and treating affective disorder following traumatic stress in humans. Neurosci Biobehav Rev 23:301–318

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE, Burton P, Shallow T, Budgell J (1999a) NMD A receptors mediate lasting increases in anxiety-like behavior produced by the stress of predator exposure — implications for anxiety associated with posttraumatic stress disorder. Physiol Behav 65:723–737

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE, Burton P, Shallow T, Budgell J (1999b) Unilateral block of NMD A receptors in the amygdala prevents predator stress-induced lasting increases in anxiety-like behavior and unconditioned startle — effect on behavior depends on the hemisphere. Physiol Behav 65:739–751

    Article  PubMed  CAS  Google Scholar 

  • Adamec R, Blundell J, Collins A (2001) Neural plasticity and stress induced changes in defense in the rat. Neurosci Biobehav Rev 25:721–744

    Article  PubMed  CAS  Google Scholar 

  • Adamec RE, Blundell J, Burton P (2003) Phosphorylated cyclic AMP response element binding protein expression induced in the periaqueductal gray by predator stress: its relationship to the stress experience, behavior and limbic neural plasticity. Prog Neuropsychopharmacol Biol Psychiat 27:1243–1267

    Article  CAS  Google Scholar 

  • Adamec R, Bartoszyk GD, Burton P (2004a) Effects of systemic injections of vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats. Eur J Pharmacol 504:65–77

    Article  PubMed  CAS  Google Scholar 

  • Adamec R, Creamer K, Bartoszyk GD, Burton P (2004b) Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats. Eur J Pharmacol 504:79–96

    Article  PubMed  CAS  Google Scholar 

  • Adamec R, Blundell J, Burton P (2005a) Effect of aggression on the brain-relationship of the predatory attack experience to neural plasticity, phosphorylated cyclic adenosine monophosphate response element binding protein (pCREB) expression and neuroendocrine response. Neurosci Biobehav Rev (in press)

    Google Scholar 

  • Adamec R, Blundell J, Burton P (2005b) Neural circuit changes mediating lasting brain and behavioral response to predator stress. Neurosci Biobehav Rev (in press)

    Google Scholar 

  • Adamec R, Strasser K, Blundell J, McKay D (2005c in press) Protein synthesis and the mechanisms of lasting change in anxiety induced by severe stress. Behav. Brain Res.

    Google Scholar 

  • Amat J, Matus-Amat P, Watkins LR, Maier SF (1998) Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat. Brain Res 812:113–120

    Article  PubMed  CAS  Google Scholar 

  • Baker JD, Azorlosa JL (1996) The NMDA antagonist MK-801 blocks the extinction of pavlovian fear conditioning. Behav Neurosci 110:618–620

    Article  PubMed  CAS  Google Scholar 

  • Barea-Rodriguez EJ, Rivera DT, Jaffe DB, Martinez JL Jr (2000) Protein synthesis inhibition blocks the induction of mossy fiber long-term potentiation in vivo. J Neurosci 20:8528–8532

    PubMed  CAS  Google Scholar 

  • Bartoszyk GD, van Amsterdam C, Bottcher H, Seyfried CA (2003) EMD 281014, a new selective serotonin 5-HT2A receptor antagonist. Eur J Pharmacol 473:229–230

    Article  PubMed  CAS  Google Scholar 

  • Bauer EP, Ledoux JE, Nader K (2001) Fear conditioning and LTP in the lateral amygdala are sensitive to the same stimulus contingencies. Nat Neurosci 4:687–688

    Article  PubMed  CAS  Google Scholar 

  • Bauer EP, Schafe GE, LeDoux JE (2002) NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. J Neurosci 22:5239–5249

    PubMed  CAS  Google Scholar 

  • Beinfeld MC (2001) An introduction to neuronal cholecystokinin. Peptides 22:1197–1200

    Article  PubMed  CAS  Google Scholar 

  • Bilang-Bleuel A, Rech J, DeCarli S, Holsboer F, Reul JMHM (2002) Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the rat. Eur J Neurosci 15:1048–1060

    Article  PubMed  CAS  Google Scholar 

  • Blair HT, Schafe GE, Bauer EP, Rodrigues SM, Ledoux JE (2001) Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. Learn Mem 8:229–242

    Article  PubMed  CAS  Google Scholar 

  • Blanchard RJ, Nikulina JN, Sakai RR, McKittrick C, McEwen B, Blanchard DC (1998) Behavioral and endocrine change following chronic predatory stress. Physiol Behav 63:561–569

    Article  PubMed  CAS  Google Scholar 

  • Blundell J, Adamec R, Burton P (2005a) Role of NMDA receptors in the lateralized potentiation of central amygdala (ACE) — periaqueductal gray (PAG) and ventral angular bundle (VAB) — basolateral amygdala (BLA) neural transmission produced by predator stress. Physiol Behav (in press)

    Google Scholar 

  • Blundell J, Adamec R, Burton P (2005b) Role of NMDA receptors in the syndrome of behavioral changes produced by predator stress. Physiol Behav (in press)

    Google Scholar 

  • Bonne O, Brandes D, Segman R, Pitman RK, Yehuda R, Shalev AY (2003) Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorder. Psychiat Res 119:171–175

    Article  CAS  Google Scholar 

  • Bradwejn J, Koszycki D (2001) Cholecystokinin and panic disorder: past and future clinical research strategies. Scand J Clin Lab Invest 61:19–27

    Article  CAS  Google Scholar 

  • Brandao ML, Anseloni VZ, Pandossio JE, De Araujo JE, Castilho VM (1999) Neurochemical mechanisms of the defensive behavior in the dorsal midbrain. Neurosci Biobehav Rev 23:863–875

    Article  PubMed  CAS  Google Scholar 

  • Butler WH (1989) The neuropathology of vigabatrin. Epilepsia [EIX] 30Suppl 3:S15–S17

    CAS  Google Scholar 

  • Cahill L, van Stegeren A (2003) Sex-related impairment of memory for emotional events with β-adrenergic blockade. Neurobiol Learn Mem 79:81–88

    Article  PubMed  CAS  Google Scholar 

  • Cahill L, Pham CA, Setlow B (2000) Impaired memory consolidation in rats produced with beta-adrenergic blockade. Neurobiol Learn Mem 74:259–266

    Article  PubMed  CAS  Google Scholar 

  • Campeau S, Miserendino MJD, Davis M (1992) Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus. Behav Neurosci 106:569–574

    Article  PubMed  CAS  Google Scholar 

  • Canteras NS, Goto M (1999) Fos-like immunoreactivity in the periaqueductal gray of rats exposed to a natural predator. NeuroReport 10:413–418

    Article  PubMed  CAS  Google Scholar 

  • Carrive P, Lee J, Su A (2000) Lidocaine blockade of amygdala output in fear-conditioned rats reduces fos expression in the ventrolateral periaqueductal gray. Neuroscience 95:1071–1080

    Article  PubMed  CAS  Google Scholar 

  • Chen A, Hough CJ, Li H (2003) Serotonin type II receptor activation facilitates synaptic plasticity via N-methyl-D-aspartate-mediated mechanism in the rat basolateral amygdala. Neuroscience 119:53–63

    Article  PubMed  CAS  Google Scholar 

  • Cohen H, Benjamin J, Kaplan Z, Kotler M (2000) Administration of high-dose ketoconazole, an inhibitor of steroid synthesis, prevents posttraumatic anxiety in an animal model. Eur Neuropsychopharmacol 10:429–435

    Article  PubMed  CAS  Google Scholar 

  • Cohen H, Zohar J, Matar M (2003) The relevance of differential response to trauma in an animal model of posttraumatic stress disorder. Biol Psychiat 53:463–473

    Article  PubMed  Google Scholar 

  • Da Costa Gomez TM, Behbehani MM (1995) An electrophysiological characterization of the projection from the central nucleus of the amygdala to the periaqueductal gray of the rat: the role of opioid receptors. Brain Res 689:21–31

    Article  PubMed  Google Scholar 

  • Das S, Grunert M, Williams L, Vincent SR (1997) NMDA and Dl receptors regulate the phosphorylation of CREB and the induction of c-fos in striatal neurons in primary culture. Synapse 25:227–233

    Article  PubMed  CAS  Google Scholar 

  • Davidson RJ, Pizzagalli D, Nitschke JB, Putnam K (2002) Depression: perspectives from affective neuroscience. Annu Rev Psychol 53:545–574

    Article  PubMed  Google Scholar 

  • Davis M (1990) Animal models of anxiety based on classical conditioning: the conditioned emotional response (CER) and the fear-potentiated startle effect. Pharmacol Therapeut 47:147–165

    Article  CAS  Google Scholar 

  • Davis M (1992) The role of the amygdala in fear-potentiated startle: implications for animal models of anxiety. Trends Pharmacol Sci 13:35–41

    Article  PubMed  CAS  Google Scholar 

  • Davis M (2002) Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy. Eur J Neurosci 16:395–398

    Article  PubMed  Google Scholar 

  • Davis HP, Squire LR (1984) Protein synthesis and memory: a review. Psychol Bull 96:518–559

    Article  PubMed  CAS  Google Scholar 

  • Davis HP, Rosenzweig MR, Bennett EL, Squire LR (1980) Inhibition of cerebral protein synthesis: dissociation of nonspecific effects and amnesic effects. Behav Neural Biol 28:99–104

    Article  PubMed  CAS  Google Scholar 

  • Davis HP, Rosenzweig MR, Kinkade PT, Bennett EL (1981) Effects of anisomycin on retention of the passive-avoidance habit as a function of age. Exp Aging Res 7:33–44

    PubMed  CAS  Google Scholar 

  • Debiec J, LeDoux JE, Nader K (2002) Cellular and systems reconsolidation in the hippocampus. Neuron 36:527–538

    Article  PubMed  CAS  Google Scholar 

  • Decola JP, Kim JJ, Fanselow MS (1991) NMDA antagonist MK-801 blocks associative fear conditioning but not nonassociative sensitization of conditional fear. Soc Neurosci Abstr 17

    Google Scholar 

  • Dielenberg RA, Carrive P, McGregor IS (2001) The cardiovascular and behavioral response to cat odor in rats: unconditioned and conditioned effects. Brain Res 897:228–237

    Article  PubMed  CAS  Google Scholar 

  • Elzinga BM, Schmahl CG, Vermetten E, Van Dyck R, Bremner JD (2003) Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology 28:1656–1665

    Article  PubMed  CAS  Google Scholar 

  • Fanselow MS, Kim JJ, Yipp J (1992) Differential reduction of fear conditioning to contextual and auditory conditional stimuli by ICV administration of an NMDA antagonist. Soc Neurosci Abstr 18

    Google Scholar 

  • Friedman MJ (1997) Drug treatment for PTSD — answers and questions. Ann N Y Acad Sci 821:359–371

    Article  PubMed  CAS  Google Scholar 

  • Goosens KA, Maren S (2002) Long-term potentiation as a substrate for memory: evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning. Hippocampus 12:592–599

    Article  PubMed  Google Scholar 

  • Hall J, Thomas KL, Everitt BJ (2001) Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala. Eur J Neurosci 13:1453–1458

    Article  PubMed  CAS  Google Scholar 

  • Holsboer F (2001) Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy. J Affect Dis 62:77–91

    Article  PubMed  CAS  Google Scholar 

  • Huang YY, Martin KC, Kandel ER (2000) Both protein kinase a and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation. J Neurosci 20:6317–6325

    PubMed  CAS  Google Scholar 

  • Ikin JF, Sim MR, Creamer MC, Forbes AB, McKenzie DP, Kelsall HL, Glass DC, McFarlane AC, Abramson MJ, Ittak P, Dwyer T, Blizzard L, Delaney KR, Horsley KWA, Harrex WK, Schwarz H (2004) War-related psychological stressors and risk of psychological disorders in Australian veterans of the 1991 Gulf War. Brit J Psychiat 185:116–126

    Article  PubMed  Google Scholar 

  • Ji JZ, Wang XM, Li BM (2003) Deficit in long-term contextual fear memory induced by blockade of β-adrenoceptors in hippocampal CA1 region. Eur J Neurosci 17:1947–1952

    Article  PubMed  Google Scholar 

  • Keck ME, Holsboer F (2001) Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders. Peptides 22:835–844

    Article  PubMed  CAS  Google Scholar 

  • Kemble ED, Blanchard DC, Blanchard RJ (1990) Effects of regional amygdaloid lesions on flight and defensive behaviors of wild black rats (Rattus rattus). Physiol Behav 48:1–5

    Article  PubMed  CAS  Google Scholar 

  • Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS (1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiat 51:8–19

    PubMed  CAS  Google Scholar 

  • Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (1995) Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiat 52:1048–1060

    PubMed  CAS  Google Scholar 

  • Kim JJ, Decola JP, Landeira-Fernandez J, Fanselow MS (1991) N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning. Behav Neurosci 105:126–133

    Article  PubMed  CAS  Google Scholar 

  • Kopchia KL, Altman HJ, Commissaris RL (1992) Effects of lesions of the central nucleus of the amygdala on anxiety-like behaviors in the rat. Pharmacol Biochem Behav 43:453–461

    Article  PubMed  CAS  Google Scholar 

  • Lee H, Kim JJ (1998) Amygdalar NMD A receptors are critical for new fear learning in previously fear-conditioned rats. J Neurosci 18:8444–8454

    PubMed  CAS  Google Scholar 

  • Lee HJ, Choi JS, Brown TH, Kim JJ (2001) Amygdalar NMDA receptors are critical for the expression of multiple conditioned fear responses. J Neurosci 21:4116–4124

    PubMed  CAS  Google Scholar 

  • Lee OK, Lee CJ, Choi S (2002) Induction mechanisms for L-LTP at thalamic input synapses to the lateral amygdala: requirement of mGluR5 activation. NeuroReport 13:685–691

    Article  PubMed  CAS  Google Scholar 

  • Liu H, Chandler S, Beitz AJ, Shipley MT, Behbehani MM (1994) Characterization of the effect of cholecystokinin (CCK) on neurons in the periaqueductal gray of the rat: immunocytochemical and in vivo and in vitro electrophysiological studies. Brain Res 642:83–94

    Article  PubMed  CAS  Google Scholar 

  • Luo B, Cheu JW, Siegel A (1998) Cholecystokinin B receptors in the periaqueductal gray potentiate defensive rage behavior elicited from the medial hypothalamus of the cat. Brain Res 796:27–37

    Article  PubMed  CAS  Google Scholar 

  • Makino S, Shibasaki T, Yamauchi N, Nishioka T, Mimoto T, Wakabayashi I, Gold PW, Hashimoto K (1999) Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat. Brain Res 850:136–143

    Article  PubMed  CAS  Google Scholar 

  • Malkani S, Rosen JB (2000a) Differential expression of EGR-1 mRNA in the amygdala following diazepam in contextual fear conditioning. Brain Res 860:53–63

    Article  PubMed  CAS  Google Scholar 

  • Malkani S, Rosen JB (2000b) Specific induction of early growth response gene I in the lateral nucleus of the amygdala following contextual fear conditioning in rats. Neuroscience 97:693–702

    Article  PubMed  CAS  Google Scholar 

  • Maren S, Fanselow MS (1995) Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. J Neurosci 15:7548–7564

    PubMed  CAS  Google Scholar 

  • Maren S, De Oca B, Fanselow MS (1994) Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning. Brain Res 661:25–34

    Article  PubMed  CAS  Google Scholar 

  • McGregor IS, Schrama L, Ambermoon P, Dielenberg RA (2002) Not all predator odours are equal: cat odour but not 2,4,5 trimethylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats. Behav Brain Res 129:1–16

    Article  PubMed  CAS  Google Scholar 

  • Moller C, Sommer W, Thorsell A, Heilig M (1999) Anxiogenic-like action of galanin after intra-amygdala administration in the rat. Neuropsychopharmacology 21:507–512

    Article  PubMed  CAS  Google Scholar 

  • Myers KM, Davis M (2002) Behavioral and neural analysis of extinction. Neuron 36:567–584

    Article  PubMed  CAS  Google Scholar 

  • Nader K, Schafe GE, LeDoux JE (2000a) Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 406:722–726

    Article  PubMed  CAS  Google Scholar 

  • Nader K, Schafe GE, LeDoux JE (2000b) The labile nature of consolidation theory. Nat Rev Neurosci 1:216–219

    Article  PubMed  CAS  Google Scholar 

  • Netto CF, Guimaraes FS (2004) Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray. Neuropsychopharmacology 29:101–107

    Article  PubMed  CAS  Google Scholar 

  • Okulski P, Hess G, Kaczmarek L (2002) Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala. Neuroscience 114:1–5

    Article  PubMed  CAS  Google Scholar 

  • Pellow S, Chopin P, File SE, Briley M (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Method 14:149–167

    Article  CAS  Google Scholar 

  • Petty F (1995) GABA and mood disorders: a brief review and hypothesis. J Affect Disord 34:275–281

    Article  PubMed  CAS  Google Scholar 

  • Pico-Alfonso MA, Garcia-Linares MI, Celda-Navarro N, Herbert J, Martinez M (2004) Changes in cortisol and dehydroepiandrosterone in women victims of physical and psychological intimate partner violence. Biol Psychiat 56:233–240

    Article  PubMed  CAS  Google Scholar 

  • Pitman RK (1997) Overview of biological themes in PTSD. Ann N Y Acad Sci 821:1–9

    Article  PubMed  CAS  Google Scholar 

  • Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, Cahill L, Orr SP (2002) Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiat 51:189–192

    Article  PubMed  CAS  Google Scholar 

  • Pollandt S, Drephal C, Albrecht D (2003) 8-OH-DPAT suppresses the induction of LTP in brain slices of the rat lateral amygdala. NeuroReport 14:895–897

    Article  PubMed  CAS  Google Scholar 

  • Rauch SL, Shin LM (1997) Functional neuroimaging studies in posttraumatic stress disorder. Ann N Y Acad Sci 821:83–98

    Article  PubMed  CAS  Google Scholar 

  • Rauch S, van der Kolk BA, Fisler RE, Alpert NM, Orr S, Savage C, Fischman A, Jenike M, Pitman R (1997a) A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiat 53:380–387

    Google Scholar 

  • Rauch SL, Savage CR, Alpert NM, Fischman AJ, Jenike MA (1997b) The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation. Biol Psychiat 42:446–452

    Article  PubMed  CAS  Google Scholar 

  • Ribeiro S, Mello CV, Velho T, Gardner TJ, Jarvis ED, Pavlides C (2002) Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep. J Neurosci 22:10914–10923

    PubMed  CAS  Google Scholar 

  • Rizvi TA, Ennis M, Behbehani MM, Shipley MT (1991) Connections between the central nucleus of the amygdala and the midbrain periaqueductal gray: topography and reciprocity. J Comp Neurol 303:121–131

    Article  PubMed  CAS  Google Scholar 

  • Rogan MT, Stäubli UV, Ledoux JE (1997) Fear conditioning induces associative long-term potentiation in the amygdala. Nature 390:604–607

    Article  PubMed  CAS  Google Scholar 

  • Rosen JB, Davis M (1990) Enhancement of electrically elicited startle by amygdaloid stimulation. Physiol Behav 48:343–349

    Article  PubMed  CAS  Google Scholar 

  • Rosen JB, Adamec R, Thompson BL (2005) Expression of egr-1 (zif268) mRNA in rat brain following exposure to a predator. Behav Brain Res (in press)

    Google Scholar 

  • Royer S, Pare D (2002) Bidirectional synaptic plasticity in intercalated amygdala neurons and the extinction of conditioned fear responses. Neuroscience 115:455–462

    Article  PubMed  CAS  Google Scholar 

  • Schafe GE, LeDoux JE (2000a) Memory consolidation of auditory Pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. J Neurosci 20:NIL5–NIL9

    Google Scholar 

  • Schafe GE, LeDoux JE (2000b) Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. J Neurosci 20:RC96:1–5

    PubMed  CAS  Google Scholar 

  • Schafe GE, Atkins CM, Swank MW, Bauer EP, Sweatt JD, LeDoux JE (2000) Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of Pavlovian fear conditioning. J Neurosci 20:8177–8187

    PubMed  CAS  Google Scholar 

  • Schafe GE, Nader K, Blair HT, LeDoux JE (2001) Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective. Trends Neurosci 24:540–546

    Article  PubMed  CAS  Google Scholar 

  • Schnyder U, Moergeli H, Trentz O, Klaghofer R, Buddeberg C (2001) Prediction of psychiatric morbidity in severely injured accident victims at one-year follow-up. Am J Respir Crit Care Med 164:653–656

    PubMed  CAS  Google Scholar 

  • Schulz S, Siemer H, Krug M, Höllt V (1999) Direct evidence for biphasic cAMP responsive element-binding protein phosphorylation during long-term potentiation in the rat dentate gyrus in vivo. J Neurosci 19:5683–5692

    PubMed  CAS  Google Scholar 

  • Seedat S, Stein MB, Kennedy CM, Hauger RL (2003) Plasma cortisol and neuropeptide Y in female victims of intimate partner violence. Psychoneuroendocrinology 28:796–808

    Article  PubMed  CAS  Google Scholar 

  • Seva C, Kowalski-Chauvel A, Daulhac L, Barthez C, Vaysse N, Pradayrol L (1997) Wortmannin-sensitive activation of p70S6-kinase and MAP-kinase by the G protein-coupled receptor, G/CCKB. Biochem Biophys Res Com 238:202–206

    Article  PubMed  CAS  Google Scholar 

  • Shalev AY, Freedman S, Peri T, Brandes D, Sahar T, Orr SP, Pitman RK (1998) Prospective study of posttraumatic stress disorder and depression following trauma. Am J Psychiat 155:630–637

    PubMed  CAS  Google Scholar 

  • Shepard JD, Barron KW, Myers DA (2000) Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior. Brain Res 861:288–295

    Article  PubMed  CAS  Google Scholar 

  • Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM, Metzger LJ, Lasko NB, Orr SP, Pitman RK (1997) A positron emission tomographic study of symptom provocation in PTSD. Ann N Y Acad Sci 821:521–523

    Article  PubMed  CAS  Google Scholar 

  • Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM, Metzger LJ, Lasko NB, Orr SP, Pitman RK (1999) Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: a PET investigation. Am J Psychiat 156:575–584

    PubMed  CAS  Google Scholar 

  • Silva AJ, Kogan JH, Frankland PW, Kida S (1998) CREB and memory. Annu Rev Neurosci 21:127–148

    Article  PubMed  CAS  Google Scholar 

  • Stanciu M, Radulovic J, Spiess J (2001) Phosphorylated cAMP response element binding protein in the mouse brain after fear conditioning: relationship to Fos production. Mol Brain Res 94:15–24

    Article  PubMed  CAS  Google Scholar 

  • Stiedl O, Birkenfeld K, Palve M, Spiess J (2000) Impairment of conditioned contextual fear of C57BL/6J mice by intracerebral injections of the NMDA receptor antagonist APV. Behav Brain Res 116:157–168

    Article  PubMed  CAS  Google Scholar 

  • Swiergiel AH, Kalin NH, Rubin WW, Takahashi LK (1992) Antagonism of CRF receptors in the central nucleus of the amygdala attenuates shock-induced freezing behavior in rats. Soc Neurosci Abstr 18

    Google Scholar 

  • Tsvetkov E, Carlezon WA, Benes FM, Kandel ER, Bolshakov VY (2002) Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala. Neuron 34:289–300

    Article  PubMed  CAS  Google Scholar 

  • Vaiva G, Ducrocq F, Jezequel K, Averland B, Lestavel P, Brunet A, Marmar CR (2003) Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol Psychiat 54:947–949

    Article  PubMed  CAS  Google Scholar 

  • Van de Kar LD, Javed A, Zhang Y, Serres F, Raap DK, Gray TS (2001) 5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells. J Neurosci 21:3572–3579

    PubMed  Google Scholar 

  • van der Kolk BA (1997) The psychobiology of posttraumatic stress disorder. J Clin Psychiat 58Suppl 9:16–24

    Google Scholar 

  • Wunderlich GR, Raymond R, DeSousa NJ, Nobrega JN, Vaccarino FJ (2002) Decreased CCKB receptor binding in rat amygdala in animals demonstrating greater anxiety-like behavior. Psychopharmacology 164:193–199

    Article  PubMed  CAS  Google Scholar 

  • Yamashita K, Kataoka Y, Shibata K, Ozaki T, Miyazaki A, Kagoshima M, Ueki S (1989) Neuroanatomical substrates regulating rat conflict behavior evidenced by brain lesioning. Neurosci Lett 104:195–200

    Article  PubMed  CAS  Google Scholar 

  • Yasui M, Kawasaki K (1995) CCKB-receptor activation augments the long-term potentiation in guinea pig hippocampal slices. Jpn J Pharmacol 68:441–447

    PubMed  CAS  Google Scholar 

  • Yehuda R, Bierer LM, Schmeidler J, Aferiat DH, Breslau I, Dolan S (2000) Low cortisol and risk for PTSD in adult offspring of Holocaust survivors. Am J Psychiat 157:1252–1259

    Article  PubMed  CAS  Google Scholar 

  • Young EA, Breslau N (2004) Cortisol and catecholamines in posttraumatic stress disorder — an epidemiologic community study. Arch Gen Psychiat 61:394–401

    Article  PubMed  CAS  Google Scholar 

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Adamec, R., Blundell, J., Strasser, K., Burton, P. (2006). Mechanisms of Lasting Change in Anxiety Induced by Severe Stress. In: Kato, N., Kawata, M., Pitman, R.K. (eds) PTSD. Springer, Tokyo. https://doi.org/10.1007/4-431-29567-4_7

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