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Allergic Contact Dermatitis in Humans — Experimental and Quantitative Aspects

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Contact Dermatitis

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References

  1. Wahlberg JE (2000) Patch testing. In: Rycroft RJG, Menné T, Frosch PJ, Lepoittevin J-P (eds) Textbook of contact dermatitis, 3rd edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  2. Andersen KE, Liden C, Hansen J, Volund A (1993) Dose-response testing with nickel sulphate using the TRUE test in nickel-sensitive individuals. Multiple nickel sulphate patch-test reactions do not cause an “angry back”. Br J Dermatol 129:50–56

    PubMed  CAS  Google Scholar 

  3. Menné T, Calvin G (1993) Concentration threshold of nonoccluded nickel exposure in nickel-sensitive individuals and controls with and without surfactant. Contact Dermatitis 29:180–184

    Article  PubMed  Google Scholar 

  4. Flyvholm MA, Hall BM, Agner T, Tiedemann E, Greenhill P, Vanderveken W, Freeberg FE, Menné T (1997) Threshold for occluded formaldehyde patch test in formaldehydesensitive patients. Relationship to repeated open application test with a product containing formaldehyde releaser. Contact Dermatitis 36:26–33

    Article  PubMed  CAS  Google Scholar 

  5. Menné T (1991) Relationship between use test and threshold patch test concentration in patients sensitive to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (MCI/MI). Contact Dermatitis 24:375

    Article  PubMed  Google Scholar 

  6. Johansen JD, Andersen KE, Menné T (1996) Quantitative aspects of isoeugenol contact allergy assessed by use and patch tests. Contact Dermatitis 34:414–418

    Article  PubMed  CAS  Google Scholar 

  7. Frosch PJ, Pilz B, Burrows D, Camarasa JG, Lachapelle JM, Lahti A, Menné T, Wilkinson JD (1995) Testing with fragrance mix. Is the addition of sorbitan sesquioleate to the constituents useful? Contact Dermatitis 32:266–272

    Article  PubMed  CAS  Google Scholar 

  8. Rudzki E, Rebandel P, Karas Z (1997) Patch testing with lower concentrations of chromate and nickel. Contact Dermatitis 37:46

    Article  PubMed  CAS  Google Scholar 

  9. Hindsen M, Bruze M (1998) The significance of previous contact dermatitis for elicitation of contact allergy to nickel. Acta Derm Venereol 78:367–370

    Article  PubMed  CAS  Google Scholar 

  10. Jensen CD, Johansen JD, Menné T, Andersen KE (2005) Increased retest activity by both patch and use test with methyldibromo glutaronitrile in sensitized individuals. Acta Derm Venereol (in press)

    Google Scholar 

  11. Johansen JD, Skov L, Volund A, Andersen K, Menné T (1998) Allergens in combination have a synergistic effect on the elicitation response: a study of fragrance-sensitized individuals. Br J Dermatol 139:264–270

    Article  PubMed  CAS  Google Scholar 

  12. Kligman AM (1966) The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers. J Invest Dermatol 47:393–409

    Article  PubMed  CAS  Google Scholar 

  13. Rees JL, Friedmann PS, Matthews JN (1990) The influence of area of application on sensitization by dinitrochlorobenzene. Br J Dermatol 122:29–31

    PubMed  CAS  Google Scholar 

  14. Upadhye MR, Maibach HI (1992) Influence of area of application of allergen on sensitization in contact dermatitis. Contact Dermatitis 27:281–286

    Article  PubMed  CAS  Google Scholar 

  15. Fewings J, Menné T (1999) An update of the risk assessment for methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) with focus on rinse-off products. Contact Dermatitis 41:1–13

    PubMed  CAS  Google Scholar 

  16. Hextall JM, Alagaratnam NJ, Glendinning AK, Holloway DB, Blaikie L, Basketter DA, McFadden JP (2002) Dose-time relationship for elicitation of contact allergy to para-phenylenediamine. Contact Dermatitis 47:96–99

    Article  PubMed  Google Scholar 

  17. Andersen KE, Johansen JD, Bruze M, Frosch PJ, Goossens A, Lepoittevin JP, Rastogi S, White I, Menné T (2001) The time-dose-response relationship for elicitation of contact dermatitis in isoeugenol allergic individuals. Toxicol Appl Pharmacol 170:166–171

    Article  PubMed  CAS  Google Scholar 

  18. Jensen CD, Johansen JD, Menné T, Andersen KE (2005) Methyldibromo glutaronitrile contact allergy: effect of single versus repeated daily exposures. Contact Dermatitis 52:88–92

    Article  PubMed  CAS  Google Scholar 

  19. Jordan WPJ, Sherman WT, King SE (1979) Threshold responses in formaldehyde-sensitive subjects. J Am Acad Dermatol 1:44–48

    Article  PubMed  Google Scholar 

  20. Heydorn S, Andersen KE, Johansen JD, Menné T (2003) A stronger patch test reaction to the allergen hydroxycitronellal and the irritant sodium lauryl sulfate. Contact Dermatitis 49:133–139

    Article  PubMed  CAS  Google Scholar 

  21. Pedersen LK, Haslund P, Johansen JD, Held E, Volund A, Agner T (2004) Influence of a detergent on skin response to methyldibromo glutaronitrile in sensitized individuals. Contact Dermatitis 50:1–5

    Article  PubMed  CAS  Google Scholar 

  22. Agner T, Johansen JD, Overgaard L, Volund A, Basketter D, Menné T (2002). Combined effects of irritants and allergens. Synergistic effects of nickel and sodium lauryl sulfate-in nickel sensitized individuals (1991). Contact Dermatitis 47:21–26

    Article  PubMed  CAS  Google Scholar 

  23. Hannuksela M (1991) Sensitivity of various skin sites in the repeated open application test. Am J Contact Dermat 2:102–104

    Google Scholar 

  24. Johansen JD, Rastogi SC, Bruze M, Andersen KE, Frosch PJ, Dreier B, Lepoittevin JP, White IR, Menné T (1998). Deodorants: a clinical provocation study in fragrance-sensitive individuals. Contact Dermatitis 39:161–165.

    PubMed  CAS  Google Scholar 

  25. Zachariae C, Hall B, Cottin M, Andersen KE, Menné T (2004). Formaldehyde allergy — clinically relevant threshold reactions. Contact Dermatitis (abstract) 50:136

    Article  Google Scholar 

  26. Hindsen M. Bruze M, Christensen OB (1999) Individual variation in nickel patch test reactivity. Am J Contact Dermat 10:62–67

    Article  PubMed  CAS  Google Scholar 

  27. Hansen MB, Johansen JD, Menné T (2003) Chromium allergy: significanse of both Cr(III) and Cr(VI). Contact Dermatitis 49:206–212

    Article  PubMed  CAS  Google Scholar 

  28. Frosch PJ, Pirker C, Rastogi SC, Andersen KE, Bruze M, Svedman C, Goossens A, White IR, Uter W, Giménez Arnau E, Lepoittevin JP, Menné T, Johansen JD (2005) Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. Contact Dermatitis 52:207–215

    Article  PubMed  CAS  Google Scholar 

  29. Gruvberger B, Andersen KE, Brandao FM, Bruynzeel DP, Bruze M, Frosch PJ, Goosens A, Lathi A, Lindberg M, Menné T, Orton D, Seidinari S (2005). Patch testing with methyldibromo glutaronitrile, a multicentre study with the EECDRG. Contact Dermatitis 52:14–18

    Article  PubMed  CAS  Google Scholar 

  30. Mortz CG, Lauritzen JM, Bindslev-Jensen C, Andersen KE (2002) Nickel sensitization in adolescents and association with ear piercing, use of braces and hand eczema. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). Acta Derm Venereol 82:352–358

    Article  PubMed  Google Scholar 

  31. Johansen JD, Frosch PJ, Svedman C, Andersen KE, Bruze M, Pirker C, Menné T (2003) Hydroxyisohexyl 3-cyclohexene carboxaldehyde — known as Lyral: quantitative aspects and risk assessment of an important fragrance allergen. Contact Dermatitis 48:310–316

    Article  PubMed  CAS  Google Scholar 

  32. Johansen JD, Andersen KE, Svedman C, Bruze M, Bernard G, Giminez-Arnau E, Rastogi SC, Lepoittevin JP, Menné T (2003) Chloroatranol an extremely potent allergen hidden in perfumes — a dose-response elicitation study. Contact Dermatitis 49:180–184

    Article  PubMed  CAS  Google Scholar 

  33. Boukhman MP, Maibach HI (2001) Thresholds in contact sensitization: immunologic mechanisms and experimental evidence in humans — an overview. Food Chem Toxicol 39:1125–1134

    Article  PubMed  CAS  Google Scholar 

  34. Trattner A, Johansen JD, Menné T (1998) Formaldehyde concentration in diagnostic patch testing: comparison of 1% with 2%. Contact Dermatitis 38:9–13

    PubMed  CAS  Google Scholar 

  35. Fischer LA, Menné T, Johansen JD (2005) Experimental nickel elicitation thresholds — a review focusing on occluded nickel exposure. Contact Dermatitis 52:57–64

    Article  PubMed  CAS  Google Scholar 

  36. Villarama CD, Maibach HI (2004) Correlations of patch test reactivity and the repeated open application test (ROAT)/provocative use test (PUT). Food Chem Toxicol 42:1719–1725

    Article  PubMed  CAS  Google Scholar 

  37. Hannuksela M, Salo H (1986) The repeated open application test (ROAT). Contact Dermatitis 14:221–227

    Article  PubMed  CAS  Google Scholar 

  38. Johansen JD, Andersen KE, Rastogi SC, Menné T (1996) Threshold responses in cinnamic-aldehyde-sensitive subjects: results and methodological aspects. Contact Dermatitis 34:165–171

    Article  PubMed  CAS  Google Scholar 

  39. Pedersen LK, Agner T, Held E, Johansen JD (2004) Methyldibromo glutaronitrile in leave-on products elicits contact allergy at low concentration. Br J Dermatol 151:817–822

    Article  CAS  Google Scholar 

  40. Rolland A, Wagner N, Chatelus A, Shroot B, Schaefer H (1993) Site-specific drug delivery to pilosebaceous structures using polymeric microspheres. Pharm Res 10:1738–1744

    Article  PubMed  CAS  Google Scholar 

  41. Vestergaard L, Clemmensen OJ, Sorensen FB, Andersen KE (1999) Histological distinction between early allergic and irritant patch test reactions: follicular spongiosis may be characteristic of early allergic contact dermatitis. Contact Dermatitis 41:207–210

    PubMed  CAS  Google Scholar 

  42. Johansen JD, Bruze M, Andersen KE, Frosch PJ, Dreier B, White IR, Rastogi S, Lepoittevin JP, Menné T (1998) The repeated open application test: suggestions for a scale of evaluation. Contact Dermatitis 39:95–96

    PubMed  CAS  Google Scholar 

  43. Held E, Lorentzen H, Agner T, Menné T (1998) Comparison between visual score and erythema index (DermaSpectrometer) in evaluation of allergic patch tests. Skin Res Technol 4:188–191

    Google Scholar 

  44. Maibach HI (1983) Formaldehyde: effects on animal and human skin. In: Gibson JE (ed) Formaldehyde toxicity. Hemisphere, Washington DC, pp 166–174

    Google Scholar 

  45. Bruze M, Johansen JD, Andersen KE, Frosch PJ, Lepoittevin JP, Rastogi S, Wakelin S, White IR, Menné T (2003) Deodorants: an experimental provocation study with cinnamic aldehyde. J Am Acad Dermatol 48:194–200

    Article  PubMed  Google Scholar 

  46. Svedman C, Bruze M, Johansen JD, Andersen KE, Goossens A, Frosch PJ, Lepoittevin JP, Rastogi S, White IR, Menné T (2003) Deodorants: an experimental provocation study with hydroxycitronellal. Contact Dermatitis 48:217–223

    Article  PubMed  CAS  Google Scholar 

  47. Frosch PJ, Lahti A, Hannuksela M, Andersen KE, Wilkinson JD, Shaw S, Lachapelle JM (1995) Chloromethylisothiazolone/methylisothiazolone (CMI/MI) use test with a shampoo on patch-test-positive subjects.Results of a multicentre double-blind crossover trial. Contact Dermatitis 32:210–217

    Article  PubMed  CAS  Google Scholar 

  48. Jensen CD, Johansen JD, Menné T, Andersen KE (2004) Methyldibromo glutaronitrile in rinse-off products causes allergic contact dermatitis: an experimental study. Br J Dermatol 150:90–95

    Article  PubMed  CAS  Google Scholar 

  49. Zachariae C, Rastogi S, Devantier Jensen C, Menné T, Johansen JD (2003). Methyldibromo glutaronitrile: clinical experience and expsoure-based risk assessment. Contact Dermatitis 48:150–154

    Article  PubMed  CAS  Google Scholar 

  50. Zachariae C, Johansen JD, Rastogi SC, Menné T (2005) Allergic contact dermatitis from methyldibromo glutaronitrile — clinical cases from 2003. Contact Dermatitis 52:6–8

    Article  PubMed  CAS  Google Scholar 

  51. Johansen JD, Veien NK, Laurberg G, Kaaber K, Thormann J, Lauritzen M, Avnstorp C (2005) Contact allergy to methyldibromo glutaronitrile — data from a front line network. Contact Dermatitis 52:138–141

    Article  PubMed  CAS  Google Scholar 

  52. Knudsen BB, Larsen E, Egsgaard H, Menné T (1993) Release of thiurams and carbamates from rubber gloves. Contact Dermatitis 28:63–69

    Article  PubMed  CAS  Google Scholar 

  53. Knudsen BB, Menné T (1996) Elicitation thresholds for thiuram mix using petrolatum and ethanol/sweat as vehicles. Contact Dermatitis 34:410–413

    Article  PubMed  CAS  Google Scholar 

  54. Hansson C, Bergendorff O, Ezzelarab M, Sterner O (1997) Extraction of mercaptobenzothiazole compounds from rubber products. Contact Dermatitis 36:195–200

    Article  PubMed  CAS  Google Scholar 

  55. Hjorth N, Roed-Petersen J (1976) Occupational protein contact dermatitis in food handlers. Contact Dermatitis 2:28–42

    Article  PubMed  CAS  Google Scholar 

  56. Christensen OB, Moller H (1975) External and internal exposure to the antigen in the hand eczema of nickel allergy. Contact Dermatitis 1:136–141

    Article  PubMed  CAS  Google Scholar 

  57. Allenby CF, Basketter DA (1994) The effect of repeated open exposure to low levels of nickel on compromised hand skin of nickel-allergic subjects. Contact Dermatitis 30:135–138

    Article  PubMed  CAS  Google Scholar 

  58. Nielsen NH, Menné T, Kristiansen J, Christensen JM, Borg L, Poulsen LK (1999) Effects of repeated skin exposures to low nickel concentrations — a model for allergic contact dermatitis to nickel on the hands. Br J Dermatol 141:676–682

    Article  PubMed  CAS  Google Scholar 

  59. Kristiansen J, Christensen JM, Henriksen T, Nielsen NH, Menné T (1999) Determination of nickel in fingernails and forearm skin (stratum corneum). Anal Chim Acta 403:265–272

    Article  Google Scholar 

  60. Peters K, Gammelgaard B, Menné T (1991) Nickel concentrations in fingernails as a measure of occupational exposure to nickel. Contact Dermatitis 25:237–241

    Article  PubMed  CAS  Google Scholar 

  61. Nielsen NH, Kristiansen J, Borg L, Christensen JM, Poulsen LK, Menné T (2000) Repeated exposures to cobalt and chromate on the hands of patients with hand eczema and the specific metal contact allergy. Contact Dermatitis 43:212–215

    Article  PubMed  CAS  Google Scholar 

  62. Heydorn S, Menné T, Andersen KE, Bruze M, Svedman C, Basketter D, Johansen JD (2003). The fragrance hand immersion study — an experimental model simulating exposure for allergic contact dermatitis on the hands. Contact Dermatitis 48:324–330

    Article  PubMed  CAS  Google Scholar 

  63. Horsfall FL (1934) Formaldehyde hypersensitiveness. An experimental study. J Immunol 27:569–581

    CAS  Google Scholar 

  64. Menné T (1994) Quantitative aspects of nickel dermatitis. Sensitization and eliciting threshold concentrations. Sci Total Environ 148:275–281

    Article  PubMed  Google Scholar 

  65. Liden C, Menné T, Burrows D (1996) Nickel-containing alloys and platings and their ability to cause dermatitis. Br J Dermatol 134:193–198

    Article  PubMed  CAS  Google Scholar 

  66. Schnuch A, Uter W (2003) Decrease in nickel allergy in Germany and regulatory interventions. Contact Dermatitis 49:107–108

    Article  PubMed  CAS  Google Scholar 

  67. Jensen CS, Lisby S, Baadsgaard O, Volund A, Menné T (2002) Decrease in nickel sensitization in a Dansih schoolgirl population with ears pierced after implementation of a nickel-exposure regulation. Br J Dermatol 146:636–642

    Article  PubMed  Google Scholar 

  68. Rastogi SC, Lepoittevin JP, Johansen JD, Frosch PJ, Menné T, Bruze M, Dreier B, Andersen KE, White IR (1998) Fragrances and other materials in deodorants: search for potentially sensitizing molecules using combined GC-MS and structure activity relationship (SAR) analysis. Contact Dermatitis 39:293–303

    PubMed  CAS  Google Scholar 

  69. Johansen JD, Rastogi SC, Menné T (1996) Contact allergy to popular perfumes; assessed by patch test, use test and chemical analysis. Br J Dermatol 135:419–422

    Article  PubMed  CAS  Google Scholar 

  70. Gruvberger B (1997) Methylisothiazolinones. Diagnosis and prevention of allergic contact dermatitis. Acta Derm Venereol [Suppl] (Stockh) 200:1–42

    CAS  Google Scholar 

  71. Frosch PJ, Johansen JD, Menné T, Pirker C, Rastogi SC, Andersen KE, Bruze M, Goossens A, Lepoittevin JP, White IR (2002) Further important sensitizers in patients sensitive to fragrances. II. Reactivity to essential oils. Contact Dermatitis 47:279–287

    Article  PubMed  CAS  Google Scholar 

  72. Fischer T, Andersen K, Bengtsson U, Frosch P, Gunnarsson Y, Kreilgard B, Menné T, Shaw S, Svensson L, Wilkinson J (1995) Clinical standardization of the TRUE Test formaldehyde patch. Curr Probl Dermatol 22:24–30

    PubMed  CAS  Google Scholar 

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Johansen, J.D., Frosch, P.J., Menné, T. (2006). Allergic Contact Dermatitis in Humans — Experimental and Quantitative Aspects. In: Frosch, P.J., Menné, T., Lepoittevin, JP. (eds) Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31301-X_13

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